Editors' ChoiceInflammation

Metabolic control of NLRP3 inflammasome by itaconation

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Science Translational Medicine  16 Sep 2020:
Vol. 12, Issue 561, eabe1714
DOI: 10.1126/scitranslmed.abe1714

Abstract

The Krebs cycle–derived immunometabolite itaconate constrains NLRP3 inflammasome activation and IL-1β release.

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