Research ArticleMetabolism

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

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Science Translational Medicine  16 Sep 2020:
Vol. 12, Issue 561, eaaz1803
DOI: 10.1126/scitranslmed.aaz1803

Article Information

vol. 12 no. 561

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 20, 2019
  • Resubmitted January 27, 2020
  • Accepted for publication August 24, 2020
  • .

Author Information

  1. Sonia García-Calzón1,2,*,
  2. Alexander Perfilyev1,
  3. Mats Martinell3,
  4. Monta Ustinova4,
  5. Sebastian Kalamajski5,
  6. Paul W. Franks5,
  7. Karl Bacos1,
  8. Ilze Elbere4,
  9. Jussi Pihlajamäki6,7,
  10. Petr Volkov1,
  11. Allan Vaag8,
  12. Leif Groop9,
  13. Marlena Maziarz10,
  14. Janis Klovins4,11,
  15. Emma Ahlqvist9 and
  16. Charlotte Ling1,*
  1. 1Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Scania University Hospital, 214 28 Malmö, Sweden.
  2. 2Department of Nutrition, Food Science and Physiology, University of Navarra, 31008 Pamplona, Spain.
  3. 3Department of Public Health and Caring Sciences, Uppsala University, 751 22 Uppsala, Sweden.
  4. 4Latvian Biomedical Research and Study Centre, Rātsupītes Street 1, k-1, Riga LV-1067, Latvia.
  5. 5Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University Diabetes Centre, 214 28 Malmö, Sweden.
  6. 6Institute of Public Health and Clinical Nutrition, Internal Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
  7. 7Clinical Nutrition and Obesity Center, Kuopio University Hospital, 70210 Kuopio, Finland.
  8. 8Type 2 Diabetes Biology Research, Steno Diabetes Center, 2820 Gentofte, Denmark.
  9. 9Genomics, Diabetes and Endocrinology Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Scania University Hospital, 214 28 Malmö, Sweden.
  10. 10Bioinformatics Unit, Department of Clinical Sciences, Lund University Diabetes Centre, 214 28 Malmö, Sweden.
  11. 11Faculty of Biology, University of Latvia, Riga LV-1004, Latvia.
  1. *Corresponding author. Email: sonia.garcia_calzon{at}med.lu.se (S.G.-C.); charlotte.ling{at}med.lu.se (C.L.)

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