Research ArticleMyocardial Infarction

Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine

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Science Translational Medicine  16 Sep 2020:
Vol. 12, Issue 561, eaay1318
DOI: 10.1126/scitranslmed.aay1318

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Enhancing cardiac recovery with exosomes

Cell transplant has been an attractive potential therapy for cardiovascular disease; however, poor cell engraftment limits efficacy of the approach. Gao and colleagues compared transplanting a mixture of human induced pluripotent stem cell–derived cardiomyocytes, endothelial cells, and smooth muscle cells to transplant of exosomes produced by these cells in a pig model of myocardial infarction. They saw similar improvements in cardiac function in cell, cell fragment, and exosome transplant groups without evidence of increased arrhythmogenicity. This suggests that exosomes could have potential as an acellular therapy for cardiovascular disease.

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