Research ArticleOsteoarthritis

ROR2 blockade as a therapy for osteoarthritis

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Science Translational Medicine  16 Sep 2020:
Vol. 12, Issue 561, eaax3063
DOI: 10.1126/scitranslmed.aax3063

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Countering cartilage breakdown

Receptor tyrosine kinase–like orphan receptor 2 (ROR2) is expressed in the cartilage during development. Here, Thorup et al. found that ROR2 signaling was increased in damaged osteoarthritic cartilage tissue and that its overexpression inhibited chondrocyte differentiation. Blocking ROR2 in a mouse model of surgically induced osteoarthritis lessened pain and improved joint architecture, and silencing ROR2 in cells promoted formation of the healthy cartilage. Results suggest that ROR2 could be a potential therapeutic target for osteoarthritis.

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