Contents
16 September 2020
Vol 12, Issue 561
Vol 12, Issue 561
Research Articles
- Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine
Cardiac cells differentiated from human induced pluripotent stem cells produce exosomes that improve recovery from myocardial infarction in pigs.
- Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect
The clinical kinetics of CLL relapse after stem cell transplant are underwritten by distinct genetic and epigenetic evolutionary trajectories.
- B cell acute lymphoblastic leukemia cells mediate RANK-RANKL–dependent bone destruction
Primary B-ALL cells cause RANKL-mediated trabecular bone and growth plate destruction in patient-derived xenograft models.
- Interleukin-2 signals converge in a lymphoid–dendritic cell pathway that promotes anticancer immunity
IL-2 immunotherapy expands tumor-infiltrating DCs through a lymphoid pathway, favoring the conversion of poorly immunogenic into immunogenic tumors.
- Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes
Blood-based epigenetic markers differentiate metformin responsiveness and tolerance in patients recently diagnosed with type 2 diabetes.
- ROR2 blockade as a therapy for osteoarthritis
ROR2 blockade improves the functional and structural outcomes of osteoarthritis in preclinical animal models by inhibiting YAP signaling.
Editors' Choice
- Metabolic control of NLRP3 inflammasome by itaconation
The Krebs cycle–derived immunometabolite itaconate constrains NLRP3 inflammasome activation and IL-1β release.
- Can eating help treat malaria?
The identification of metabolic control of the Plasmodium life cycle may open novel avenues for malaria treatment.
- Memory at the margins: Antipsychotic enhances the binding of fear memory with its context
A nontraditional antipsychotic medication enhances healthy memory function in a mouse model of fear conditioning.
About The Cover
ONLINE COVER Mitigating Myocardial Infarction. This immunofluorescence image shows the border zone of porcine heart tissue treated with cardiac cell–derived exosomes after myocardial infarction. Cell therapy is mediated in part by factors secreted from transplanted cells, which are contained in exosomes. Gao et al. compared transplant of a mixture of cardiomyocytes, smooth muscle cells, and endothelial cells derived from human induced pluripotent stem cells to exosomes purified from these cells or fragmented cells in pigs after myocardial infarction. Treatments improved cardiac function and limited hypertrophy without increasing arrhythmia, suggesting exosome transplant could have potential as an acellular therapy for cardiovascular disease. [CREDIT: GAO ET AL./SCIENCE TRANSLATIONAL MEDICINE]
