Research ArticleImaging

Ultrasensitive molecular imaging of intestinal mucosal inflammation using leukocyte-mimicking particles targeted to MAdCAM-1 in mice

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Science Translational Medicine  09 Sep 2020:
Vol. 12, Issue 560, eaaz4047
DOI: 10.1126/scitranslmed.aaz4047

Imaging intestinal inflammation

As an alternative to ileocolonoscopy with biopsy required to diagnose and monitor inflammatory bowel diseases, Fournier et al. investigated the use of magnetic resonance imaging with microsized particles of iron oxide targeting mucosal vascular addressin cell adhesion molecule 1 on inflamed mucosal tissues. They showed that the contrast agent bound to activated endothelium in the gastrointestinal tract and could be used to visualize inflammation in mouse models of colitis. Therapeutic response to atorvastatin or anti-TNF antibody could also be monitored using the contrast agent. Results support use of the molecular imaging for noninvasive diagnosis and monitoring of mucosal inflammation.

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