Research ArticleCancer

Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade

See allHide authors and affiliations

Science Translational Medicine  09 Sep 2020:
Vol. 12, Issue 560, eaax2282
DOI: 10.1126/scitranslmed.aax2282

Article Information

vol. 12 no. 560

Print ISSN: 
Online ISSN: 
  • Received for publication March 5, 2019
  • Resubmitted December 22, 2019
  • Accepted for publication July 23, 2020
  • .

Author Information

  1. Liangliang Wang1,*,
  2. Yan Gao1,2,*,
  3. Gao Zhang3,*,
  4. Dan Li1,*,
  5. Zhenda Wang1,
  6. Jie Zhang4,
  7. Leandro C. Hermida5,6,
  8. Lei He1,
  9. Zhisong Wang1,
  10. Jingwen Si1,
  11. Shuang Geng7,
  12. Rizi Ai8,
  13. Fei Ning9,
  14. Chaoran Cheng4,
  15. Haiteng Deng10,
  16. Dimiter S. Dimitrov11,
  17. Yan Sun12,
  18. Yanyi Huang7,
  19. Dong Wang13,
  20. Xiaoyu Hu9,,
  21. Zhi Wei4,,
  22. Wei Wang8, and
  23. Xuebin Liao1,
  1. 1School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Human Brain Protection, Tsinghua University, Beijing 100084, China.
  2. 2Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100006, China.
  3. 3Department of Neurosurgery and The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.
  4. 4Department of Computer Science, College of Computing Sciences, New Jersey Institute of Technology, Neswark, NJ 07102, USA.
  5. 5Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  6. 6Center for Bioinformatics and Computational Biology, Department of Computer Science, University of Maryland, College Park, MD 20742, USA.
  7. 7Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), College of Chemistry, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
  8. 8Department of Chemistry and Biochemistry, 9500 Gilman Drive, UC San Diego, La Jolla, CA 92093, USA.
  9. 9Institute of Immunology and School of Medicine, Tsinghua University, Beijing 100084, China.
  10. 10MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  11. 11Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  12. 12Lanzhou Institute of Husbandry and Pharmaceutical Science of CAAS, Lanzhou 730050, China.
  13. 13School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  1. Corresponding author. Email: xiaoyuhu{at} (X.H.); zhiwei04{at} (Z. Wei); wei-wang{at} (W.W.); liaoxuebin{at} (X.L.)
  • * These authors contributed equally to this work.


Article usage

Article usage: September 2020 to April 2021

Sep 202046201470682
Oct 202032212794
Nov 202028910677
Dec 202020211296
Jan 20212087464
Feb 20211254651
Mar 2021233130164
Apr 2021463428

Stay Connected to Science Translational Medicine