Research ArticleNEURODEGENERATIVE DISORDERS

C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy

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Science Translational Medicine  02 Sep 2020:
Vol. 12, Issue 559, eabb3774
DOI: 10.1126/scitranslmed.abb3774

Article Information

vol. 12 no. 559

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 20, 2020
  • Accepted for publication June 19, 2020
  • .

Author Information

  1. Casey N. Cook1,2,*,
  2. Yanwei Wu1,*,
  3. Hana M. Odeh3,*,
  4. Tania F. Gendron1,2,
  5. Karen Jansen-West1,
  6. Giulia del Rosso1,
  7. Mei Yue1,
  8. Peizhou Jiang1,
  9. Edward Gomes3,
  10. Jimei Tong1,
  11. Lillian M. Daughrity1,
  12. Nicole M. Avendano1,
  13. Monica Castanedes-Casey1,
  14. Wei Shao1,
  15. Björn Oskarsson4,
  16. Giulio S. Tomassy5,
  17. Alexander McCampbell5,
  18. Frank Rigo6,
  19. Dennis W. Dickson1,2,
  20. James Shorter3,,
  21. Yong-Jie Zhang1,2, and
  22. Leonard Petrucelli1,2,
  1. 1Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  2. 2Neurobiology of Disease Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN 55902, USA.
  3. 3Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  4. 4Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
  5. 5Neurology Research, Biogen Idec, Cambridge, MA 02142, USA.
  6. 6Ionis Pharmaceuticals, Carlsbad, CA 92010, USA.
  1. Corresponding author. Email: petrucelli.leonard{at}mayo.edu (L.P.); zhang.yongjie{at}mayo.edu (Y.-J.Z.); jshorter{at}pennmedicine.upenn.edu (J.S.)
  • * These authors contributed equally to this work.

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