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Research ArticleCancer
A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components
- View ORCID ProfileMonique B. Nilsson1,
- View ORCID ProfileHuiying Sun1,
- View ORCID ProfileJacqulyne Robichaux1,
- View ORCID ProfileMatthias Pfeifer2,
- View ORCID ProfileUltan McDermott2,
- Jon Travers2,
- View ORCID ProfileLixia Diao3,
- Yuanxin Xi3,
- Pan Tong3,
- Li Shen3,
- View ORCID ProfileMia Hofstad1,*,
- Masanori Kawakami1,†,
- Xiuning Le1,
- Xi Liu1,‡,
- View ORCID ProfileYouhong Fan1,
- View ORCID ProfileAlissa Poteete1,
- Limei Hu1,
- View ORCID ProfileMarcelo V. Negrao1,
- View ORCID ProfileHai Tran1,
- Ethan Dmitrovsky1,‡,
- View ORCID ProfileDavid Peng1,§,
- View ORCID ProfileDon L. Gibbons1,
- View ORCID ProfileJing Wang3 and
- View ORCID ProfileJohn V. Heymach1,||
- 1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 2Oncology R&D, AstraZeneca, Cambridge, CB2 0RE, UK.
- 3Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- ↵||Corresponding author. Email: jheymach{at}mdanderson.org
↵* Present address: University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
↵† Present address: University of Tokyo Graduate School of Medicine, Tokyo 113-8654, Japan.
↵‡ Present address: Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
↵§ Present address: New York University Langone Medical Center, New York, NY 10016, USA.
See allHide authors and affiliations
Science Translational Medicine 02 Sep 2020:
Vol. 12, Issue 559, eaaz4589
DOI: 10.1126/scitranslmed.aaz4589
Vol. 12, Issue 559, eaaz4589
DOI: 10.1126/scitranslmed.aaz4589
Monique B. Nilsson
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Huiying Sun
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jacqulyne Robichaux
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Matthias Pfeifer
2Oncology R&D, AstraZeneca, Cambridge, CB2 0RE, UK.
Ultan McDermott
2Oncology R&D, AstraZeneca, Cambridge, CB2 0RE, UK.
Jon Travers
2Oncology R&D, AstraZeneca, Cambridge, CB2 0RE, UK.
Lixia Diao
3Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Yuanxin Xi
3Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Pan Tong
3Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Li Shen
3Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mia Hofstad
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Masanori Kawakami
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Xiuning Le
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Xi Liu
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Youhong Fan
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Alissa Poteete
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Limei Hu
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Marcelo V. Negrao
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hai Tran
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Ethan Dmitrovsky
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
David Peng
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Don L. Gibbons
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jing Wang
3Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
John V. Heymach
1Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
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