Contents

Research Articles

• Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors

  By Anthony K. Park, Yuman Fong, Sang-In Kim, Jason Yang, John P. Murad, Jianming Lu, Brook Jeang, Wen-Chung Chang, Nanhai G. Chen, Sandra H. Thomas, Stephen J. Forman, Saul J. Priceman

  Science Translational Medicine02 Sep 2020 Full AccessRestricted Access

  An effective combination immunotherapy using oncolytic viruses delivers de novo CD19 to promote CD19-CAR T cell therapy against solid tumors in mice.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy

  By Casey N. Cook, Yanwei Wu, Hana M. Odeh, Tania F. Gendron, Karen Jansen-West, Giulia del Rosso, Mei Yue, Peizhou Jiang, Edward Gomes, Jimei Tong, Lillian M. Daughrity, Nicole M. Avendano, Monica Castanedes-Casey, Wei Shao, Björn Oskarsson, Giulio S. Tomassy, Alexander McCampbell, Frank Rigo, Dennis W. Dickson, James Shorter, Yong-Jie Zhang, Leonard Petrucelli

  Science Translational Medicine02 Sep 2020 Full AccessRestricted Access

  G₄C₂ repeat–derived poly(GR) plays a key role in mediating TDP-43 mislocalization and aggregation in vitro and in vivo.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis

  By Suzanne E. Eldridge, Aida Barawi, Hui Wang, Anke J. Roelofs, Magdalena Kaneva, Zeyu Guan, Helen Lydon, Bethan L. Thomas, Anne-Sophie Thorup, Beatriz F. Fernandez, Sara Caxaria, Danielle Strachan, Ahmed Ali, Kanatheepan Shanmuganathan, Costantino Pitzalis, James R. Whiteford, Frances Henson, Andrew W. McCaskie, Cosimo De Bari, Francesco Dell’Accio

  Science Translational Medicine02 Sep 2020 Full AccessRestricted Access

  Agrin heals joint surfaces by recruiting joint stem cells and inducing the formation of cartilage and bone with correct architecture in mice and sheep.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

  By Monique B. Nilsson, Huiying Sun, Jacqulyne Robichaux, Matthias Pfeifer, Ultan McDermott, Jon Travers, Lixia Diao, Yuanxin Xi, Pan Tong, Li Shen, Mia Hofstad, Masanori Kawakami, Xiuning Le, Xi Liu, Youhong Fan, Alissa Poteete, Limei Hu, Marcelo V. Negrao, Hai Tran, Ethan Dmitrovsky, David Peng, Don L. Gibbons, Jing Wang, John V. Heymach

  Science Translational Medicine02 Sep 2020 Full AccessRestricted Access

  YAP and FOXM1 are mediators of EGFR inhibitor resistance, and spindle proteins are therapeutic targets for this multidrug-resistant phenotype.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

  By Magdalene K. Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta, David Roberts, Cheng Huang, Ralf B. Schittenhelm, Andrew Ryan, Scott L. Townley, Luke A. Selth, Trevor J. Biden, Gregory R. Steinberg, Dorit Samocha-Bonet, Ruth C. R. Meex, Matthew J. Watt

  Science Translational Medicine02 Sep 2020 Full AccessRestricted Access

  SMOC1 is a liver-secreted glucose-responsive protein that improves glycemic control through CREB-mediated suppression of hepatic glucose output.

  • Editor's Summary
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  • Supplementary Materials

• A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations

  By Ludivine Grzelak, Sarah Temmam, Cyril Planchais, Caroline Demeret, Laura Tondeur, Christèle Huon, Florence Guivel-Benhassine, Isabelle Staropoli, Maxime Chazal, Jeremy Dufloo, Delphine Planas, Julian Buchrieser, Maaran Michael Rajah, Remy Robinot, Françoise Porrot, Mélanie Albert, Kuang-Yu Chen, Bernadette Crescenzo-Chaigne, Flora Donati, François Anna, Philippe Souque, Marion Gransagne, Jacques Bellalou, Mireille Nowakowski, Marija Backovic, Lila Bouadma, Lucie Le Fevre, Quentin Le Hingrat, Diane Descamps, Annabelle Pourbaix, Cédric Laouénan, Jade Ghosn, Yazdan Yazdanpanah, Camille Besombes, Nathalie Jolly, Sandrine Pellerin-Fernandes, Olivia Cheny, Marie-Noëlle Ungeheuer, Guillaume Mellon, Pascal Morel, Simon Rolland, Felix A. Rey, Sylvie Behillil, Vincent Enouf, Audrey Lemaitre, Marie-Aude Créach, Stephane Petres, Nicolas Escriou, Pierre Charneau, Arnaud Fontanet, Bruno Hoen, Timothée Bruel, Marc Eloit, Hugo Mouquet, Olivier Schwartz, Sylvie van der Werf

  Science Translational Medicine02 Sep 2020 Full AccessRestricted Access

  Different serological assays measuring anti–SARS-CoV-2 antibodies and their neutralizing activity in samples from individuals with severe and mild COVID-19 are compared.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials