Research ArticleMetabolism

CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice

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Science Translational Medicine  26 Aug 2020:
Vol. 12, Issue 558, eaaz8664
DOI: 10.1126/scitranslmed.aaz8664

Article Information

vol. 12 no. 558

Print ISSN: 
Online ISSN: 
  • Received for publication October 16, 2019
  • Resubmitted February 24, 2020
  • Accepted for publication August 3, 2020
  • .

Author Information

  1. Chih-Hao Wang1,2,
  2. Morten Lundh1,3,4,
  3. Accalia Fu5,6,
  4. Rókus Kriszt7,8,
  5. Tian Lian Huang1,
  6. Matthew D. Lynes1,
  7. Luiz O. Leiria9,10,
  8. Farnaz Shamsi1,
  9. Justin Darcy1,
  10. Bennett P. Greenwood11,
  11. Niven R. Narain11,
  12. Vladimir Tolstikov11,
  13. Kyle L. Smith12,
  14. Brice Emanuelli3,
  15. Young-Tae Chang13,14,
  16. Susan Hagen12,
  17. Nika N. Danial5,
  18. Michael A. Kiebish11 and
  19. Yu-Hua Tseng1,15,*
  1. 1Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
  2. 2Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
  3. 3Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Denmark.
  4. 4Gubra Aps, Hørsholm, DK-2970, Denmark.
  5. 5Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
  6. 6Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA.
  7. 7Department of Biomedical Engineering, National University of Singapore, Singapore, 117583.
  8. 8Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore, Singapore 119077, Singapore.
  9. 9Department of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, 14049-900, Brazil.
  10. 10Center of Research of Inflammatory Diseases, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, 14049-900, Brazil.
  11. 11BERG, Framingham, MA 01701, USA.
  12. 12Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  13. 13Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 34126, Republic of Korea.
  14. 14Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea.
  15. 15Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
  1. *Corresponding author. Email: yu-hua.tseng{at}


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