Research ArticleEpilepsy

Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome

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Science Translational Medicine  26 Aug 2020:
Vol. 12, Issue 558, eaaz6100
DOI: 10.1126/scitranslmed.aaz6100

Article Information

vol. 12 no. 558

PubMed: 
Print ISSN: 
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History: 
  • Received for publication September 24, 2019
  • Resubmitted March 27, 2020
  • Accepted for publication June 3, 2020
  • .

Author Information

  1. Zhou Han1,
  2. Chunling Chen2,
  3. Anne Christiansen1,
  4. Sophina Ji1,
  5. Qian Lin1,
  6. Charles Anumonwo2,
  7. Chante Liu2,
  8. Steven C. Leiser3,
  9. Meena1,
  10. Isabel Aznarez1,
  11. Gene Liau1 and
  12. Lori L. Isom2,*
  1. 1Stoke Therapeutics Inc., Bedford, MA 01730, USA.
  2. 2Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
  3. 3PsychoGenics Inc., Paramus, NJ 07652, USA.
  1. *Corresponding author. Email: lisom{at}umich.edu

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