Research ArticleAlzheimer’s Disease

A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease

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Science Translational Medicine  26 Aug 2020:
Vol. 12, Issue 558, eaaz5677
DOI: 10.1126/scitranslmed.aaz5677

Article Information

vol. 12 no. 558

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 19, 2019
  • Accepted for publication January 21, 2020
  • .

Author Information

  1. Emily J. Davis1,2,*,
  2. Lauren Broestl1,*,,
  3. Samira Abdulai-Saiku1,
  4. Kurtresha Worden1,,
  5. Luke W. Bonham1,3,
  6. Elena Miñones-Moyano1,§,
  7. Arturo J. Moreno1,
  8. Dan Wang1,
  9. Kevin Chang1,
  10. Gina Williams1,4,
  11. Bayardo I. Garay1,||,
  12. Iryna Lobach5,
  13. Nino Devidze6,,
  14. Daniel Kim6,
  15. Cliff Anderson-Bergman7,#,
  16. Gui-Qiu Yu6,
  17. Charles C. White8,9,
  18. Julie A. Harris10,
  19. Bruce L. Miller1,3,
  20. David A. Bennett11,
  21. Arthur P. Arnold12,
  22. Phil L. De Jager9,
  23. Jorge J. Palop1,2,4,6,
  24. Barbara Panning13,
  25. Jennifer S. Yokoyama1,3,14,
  26. Lennart Mucke1,2,4,6 and
  27. Dena B. Dubal1,2,4,**
  1. 1Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
  2. 2Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
  3. 3Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94158, USA.
  4. 4Neurosciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.
  5. 5Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA.
  6. 6Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
  7. 7Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.
  8. 8Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  9. 9Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
  10. 10Allen Institute for Brain Science, Seattle, WA 98109, USA.
  11. 11Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
  12. 12Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  13. 13Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
  14. 14Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94143, USA.
  1. **Corresponding author. Email: dena.dubal{at}ucsf.edu
  • * These authors contributed equally to this work.

  • Present address: Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63130, USA.

  • Present address: Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

  • § Present address: Synthego Corporation, Menlo Park, CA 94025, USA.

  • || Present address: University of Minnesota Medical School, Minneapolis, MN 55455, USA.

  • Present address: Sparks Therapeutics Inc., Philadelphia, PA 19104, USA.

  • # Present address: Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.

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