Research ArticleTransplantation

Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells

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Science Translational Medicine  19 Aug 2020:
Vol. 12, Issue 557, eaaz3866
DOI: 10.1126/scitranslmed.aaz3866

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Regulating the regulatory cells

Regulatory T cells (Tregs) are antigen-specific immunosuppressive cells that help prevent undesired immune responses. Chimeric antigen receptors (CARs) are engineered T cell receptors that allow direct recognition of a target antigen without requiring antigen presentation. CARs, most often, have been used with conventional T cells, directing them to attack cancer cells, for example. CAR Tregs have also been developed for treating autoimmune disorders or transplant rejection, but their biology is not as well understood. Dawson et al. addressed this knowledge gap by systematically studying and optimizing CAR signaling domains in Tregs and then applying them to a mouse model of graft-versus-host disease.

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