Research ArticleRESPIRATORY DISEASE

Pathophysiological regulation of lung function by the free fatty acid receptor FFA4

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Science Translational Medicine  19 Aug 2020:
Vol. 12, Issue 557, eaaw9009
DOI: 10.1126/scitranslmed.aaw9009

Breathing easy

Asthma and chronic obstructive pulmonary disease result in airway swelling that hinders breathing. Prihandoko et al. found that intranasal delivery of a free fatty acid receptor 4 (FFA4) agonist reduced airway resistance in mouse models of acute and chronic ozone pollution–mediated inflammation as well as house dust mite and cigarette smoke–induced inflammation. This airway relaxation was mediated in part by the release of prostaglandin PGE2. FFA4 agonism also mediated smooth muscle relaxation of ex vivo human airway samples, suggesting FFA4 as a potential respiratory disease target in humans.

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