Contents
19 August 2020
Vol 12, Issue 557
Vol 12, Issue 557
Research Articles
- Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency
Radial artery deviation and reimplantation exhibits improved patency rates in both sexes and is associated with improved hemodynamics in a rat model.
- Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells
Comparison of 10 co-receptor variant CARs revealed a requirement for CD28wt for optimal suppression by human regulatory T cells.
- Pathophysiological regulation of lung function by the free fatty acid receptor FFA4
FFA4 receptor agonism corrects dysfunctional lung responses and inflammation in models and is a potential target for inflammatory lung disease.
- De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection
A cancer evaluation criterion based on T cell receptors is potentially useful for noninvasive early cancer detection.
- Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
Acid ceramidase inhibition promotes YAP/TAZ degradation to inactivate fibroblasts, decrease matrix stiffness, and reduce fibrosis in mice.
Report
- 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice
Optimized small-molecule 3C-like protease inhibitors show potency against human coronaviruses in both cell culture and a mouse model.
Editors' Choice
- Considering COVID-19 kidney injury
Does SARS-CoV-2 infection have long-term effects on the kidney?
- An affinity for pure drugs
High-affinity supramolecular interactions improve the purification of recombinant therapeutic proteins, simplifying their production.
- It’s all about the X
Genes expressed on the X chromosome affect body weight and body fat composition.
About The Cover
ONLINE COVER Putting Fistulae on the RADAR. This simulation shows the spatial distribution of pressure in rat arteriovenous fistulae. Arteriovenous fistulae are created for hemodialysis access. Bai et al. showed that artery-to-vein fistulae created using radial artery deviation and reimplantation (RADAR) improved vessel maturity and long-term patency as compared to traditional vein-to-artery-oriented fistulae. Testing in rodent models and patients with chronic kidney disease confirmed that the RADAR technique improved hemodynamics and reduced reintervention rates. [CREDIT: BAI ET AL./SCIENCE TRANSLATIONAL MEDICINE]
