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Research ArticleMultiple Sclerosis
Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes
- View ORCID ProfileLaurent Calvier1,2,*,
- Guillaume Demuth1,2,
- Navid Manouchehri3,
- View ORCID ProfileConnie Wong1,2,
- View ORCID ProfileAnastasia Sacharidou4,
- View ORCID ProfileChieko Mineo4,
- Philip W. Shaul4,
- Nancy L. Monson3,
- Maria Z. Kounnas5,
- Olaf Stüve3,6 and
- View ORCID ProfileJoachim Herz1,2,3,7,*
- 1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
- 2Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
- 3Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
- 4Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
- 5Reelin Therapeutics Inc. La Jolla, CA 92037, USA.
- 6Department of Neurology, VA North Texas Health Care System, Medical Service, Dallas, TX 75390, USA.
- 7Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
- ↵*Corresponding author. Email: calvier.laurent{at}gmail.com (L.C.); joachim.herz{at}utsouthwestern.edu (J.H.)
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Science Translational Medicine 12 Aug 2020:
Vol. 12, Issue 556, eaay7675
DOI: 10.1126/scitranslmed.aay7675
Vol. 12, Issue 556, eaay7675
DOI: 10.1126/scitranslmed.aay7675
Laurent Calvier
1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
2Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Guillaume Demuth
1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
2Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Navid Manouchehri
3Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Connie Wong
1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
2Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Anastasia Sacharidou
4Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Chieko Mineo
4Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Philip W. Shaul
4Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Nancy L. Monson
3Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Maria Z. Kounnas
5Reelin Therapeutics Inc. La Jolla, CA 92037, USA.
Olaf Stüve
3Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
6Department of Neurology, VA North Texas Health Care System, Medical Service, Dallas, TX 75390, USA.
Joachim Herz
1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
2Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
3Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
7Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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