Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes

Laurent Calvier; Guillaume Demuth; Navid Manouchehri; Connie Wong; Anastasia Sacharidou; Chieko Mineo; Philip W. Shaul; Nancy L. Monson; Maria Z. Kounnas; Olaf Stüve; Joachim Herz

doi:10.1126/scitranslmed.aay7675

Research ArticleMultiple Sclerosis

Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes

View ORCID ProfileLaurent Calvier ¹,²,*,
Guillaume Demuth¹,²,
Navid Manouchehri³,
View ORCID ProfileConnie Wong¹,²,
View ORCID ProfileAnastasia Sacharidou⁴,
View ORCID ProfileChieko Mineo⁴,
Philip W. Shaul⁴,
Nancy L. Monson³,
Maria Z. Kounnas⁵,
Olaf Stüve³,⁶ and
View ORCID ProfileJoachim Herz ¹,²,³,⁷,*

¹Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
²Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
³Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
⁴Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
⁵Reelin Therapeutics Inc. La Jolla, CA 92037, USA.
⁶Department of Neurology, VA North Texas Health Care System, Medical Service, Dallas, TX 75390, USA.
⁷Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

↵*Corresponding author. Email: calvier.laurent{at}gmail.com (L.C.); joachim.herz{at}utsouthwestern.edu (J.H.)

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Science Translational Medicine 12 Aug 2020:
Vol. 12, Issue 556, eaay7675
DOI: 10.1126/scitranslmed.aay7675

Laurent Calvier

1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

2Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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ORCID record for Laurent Calvier
For correspondence: calvier.laurent@gmail.com joachim.herz@utsouthwestern.edu

Guillaume Demuth

1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

2Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Navid Manouchehri

3Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Connie Wong

1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

2Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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ORCID record for Connie Wong

Anastasia Sacharidou

4Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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ORCID record for Anastasia Sacharidou

Chieko Mineo

4Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Philip W. Shaul

4Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Nancy L. Monson

3Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Maria Z. Kounnas

5Reelin Therapeutics Inc. La Jolla, CA 92037, USA.

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Olaf Stüve

3Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

6Department of Neurology, VA North Texas Health Care System, Medical Service, Dallas, TX 75390, USA.

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Joachim Herz

1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

2Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

3Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

7Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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ORCID record for Joachim Herz
For correspondence: calvier.laurent@gmail.com joachim.herz@utsouthwestern.edu

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Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes

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