Research ArticleMultiple Sclerosis

Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes

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Science Translational Medicine  12 Aug 2020:
Vol. 12, Issue 556, eaay7675
DOI: 10.1126/scitranslmed.aay7675

Relying on Reelin

In multiple sclerosis (MS), the recruitment of immune cell into the brain contributes to neuroinflammation and consequent demyelination. Current approaches for inhibiting cellular infiltration have been shown to have therapeutic effects but present complications. In this study, Calvier et al. showed that the protein Reelin could be a therapeutic target in MS. Reelin was increased during relapses in serum of patients with relapsing-remitting MS. Genetic Reelin depletion in a mouse model of MS prevented monocyte extravasation and prevented paralysis. Using a pharmacologic approach, the authors showed that prophylactic or therapeutic Reelin inhibition had therapeutic effect in mice, suggesting that Reelin inhibition might be effective for treating MS.

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