Research ArticleMICROBIOTA

Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice

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Science Translational Medicine  12 Aug 2020:
Vol. 12, Issue 556, eaau9959
DOI: 10.1126/scitranslmed.aau9959

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Linking hyperoxia to microbial dysbiosis

Inhaled oxygen is a commonly administered therapy that causes severe lung injury in animals and is associated with poor clinical outcomes in humans. The bacteria that live within the body’s lungs and gut are highly variable in their tolerance of oxygen. Ashley et al. now report that in both humans and mice, inhaled oxygen influenced respiratory bacterial communities. In mice, variations in lung and gut bacterial communities correlated with the severity of lung injury, and germ-free mice were protected from oxygen-induced lung injury. These results suggest that the bacteria of our lungs and gut play an important role in the pathogenesis of oxygen-induced lung injury.

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