Contents
12 August 2020
Vol 12, Issue 556
Vol 12, Issue 556
Research Article
- Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy
Microfabricated particles mimic multiple intratumoral injections of STING agonist over weeks to improve ease of use and decrease metastasis.
Research Resource
- Predicting functional effects of missense variants in voltage-gated sodium and calcium channels
A machine learning method can predict loss- versus gain-of-function effects of human genetic variants in disease-associated ion channels.
Research Articles
- Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes
Anti-Reelin is a therapeutic approach that selectively targets endothelial adhesion of leukocytes, blocking neuroinflammation and demyelination.
- Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients
Donor fecal microbiota transplantation restores gut microbial diversity and reduces graft-versus-host disease in hematopoietic cell transplant recipients.
- Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice
Inhaled oxygen alters the microbiota of mice and humans, which may contribute to oxygen-induced lung injury.
- A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples
A colorimetric isothermal RNA amplification method was shown to detect SARS-CoV-2 RNA in clinical samples with excellent sensitivity and specificity.
Editors' Choice
- These nanoparticles are just right
Optimizing nanoparticle size, charge, and route of delivery enables highly efficient and selective targeting of tumor-associated macrophages.
- Genetic ultrasonic biosensor for picturing proteases
A genetically encoded biosensor allows noninvasive imaging of protease activity using ultrasound.
- A gut feeling to stress enhances neutrophil-mediated vascular occlusion
Psychological stress alters TH17 cell response to gut microbiome and triggers acute vascular-occlusion induced by aged-neutrophils in sickle cell disease.
About The Cover
ONLINE COVER A Box Set to Treat Cancer. The boxes in this image are microfabricated particles, ready to be loaded with a stimulator of interferon gene (STING) agonist for anticancer immunotherapy. STING agonists require repeated intratumoral injections over the course of months, which are unpleasant for patients at best and not possible when tumors are located in deep organs. Lu et al. engineered microparticles to release doses of STING agonist at different time intervals such that a single injection or implantation of particles provides a complete course of treatment. [CREDIT: XUEGUANG LU, ZACHARY TOCHKA]
