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An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

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Science Translational Medicine  05 Aug 2020:
Vol. 12, Issue 555, eabc9396
DOI: 10.1126/scitranslmed.abc9396

Article Information

vol. 12 no. 555

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Print ISSN: 
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History: 
  • Received for publication May 21, 2020
  • Accepted for publication July 16, 2020
  • .

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Author Information

  1. Jesse H. Erasmus1,2,
  2. Amit P. Khandhar2,3,
  3. Megan A. O’Connor1,4,
  4. Alexandra C. Walls5,
  5. Emily A. Hemann6,7,
  6. Patience Murapa1,
  7. Jacob Archer1,3,
  8. Shanna Leventhal8,
  9. James T. Fuller1,
  10. Thomas B. Lewis1,4,
  11. Kevin E. Draves1,
  12. Samantha Randall1,
  13. Kathryn A. Guerriero4,
  14. Malcolm S. Duthie2,
  15. Darrick Carter2,3,6,
  16. Steven G. Reed2,6,
  17. David W. Hawman8,
  18. Heinz Feldmann8,
  19. Michael Gale Jr.4,6,7,
  20. David Veesler5,
  21. Peter Berglund2 and
  22. Deborah Heydenburg Fuller1,4,6,*
  1. 1Department of Microbiology, University of Washington, Seattle, WA 98109, USA.
  2. 2HDT Bio, Seattle, WA 98102, USA.
  3. 3PAI Life Sciences, Seattle, WA 98102, USA.
  4. 4Washington National Primate Research Center, Seattle, WA 98121, USA.
  5. 5Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  6. 6Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.
  7. 7Department of Immunology, University of Washington, Seattle, WA 98109, USA.
  8. 8Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  1. *Corresponding author. Email: fullerdh{at}uw.edu

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Aug 202028970172121
Sep 202016931271117
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Nov 20201742644747
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