Research ArticleCORONAVIRUS

An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

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Science Translational Medicine  05 Aug 2020:
Vol. 12, Issue 555, eabc9396
DOI: 10.1126/scitranslmed.abc9396

stm.sciencemag.org/cgi/content/full/12/555/eabc9396/DC1

Fig. S1. Breadth of T cell responses in C57BL/6 and BALB/c mice.

Fig. S2. Vaccination did not induce adverse reactions in pigtail macaques.

Fig. S3. Raw ELISA absorbance values for pigtail macaques.

Fig. S4. Neutralization curves for pigtail macaque and human samples against SARS-CoV-2/WA/2020 or pseudotyped virus.

Fig. S5. Gating strategies used for evaluation of peptide-specific intracellular cytokine staining.

Fig. S6. LION/repRNA-CoV2S induces memory T cell responses in pigtail macaques.

Table S1. Convalescent sera from individuals with COVID-19.

Data file S1. Source data for all figures.