CytoPAN—Portable cellular analyses for rapid point-of-care cancer diagnosis

Jouha Min; Lip Ket Chin; Juhyun Oh; Christian Landeros; Claudio Vinegoni; Jeeyeon Lee; Soo Jung Lee; Jee Young Park; Ai-Qun Liu; Cesar M. Castro; Hakho Lee; Hyungsoon Im; Ralph Weissleder

doi:10.1126/scitranslmed.aaz9746

Research ArticleCancer

CytoPAN—Portable cellular analyses for rapid point-of-care cancer diagnosis

View ORCID ProfileJouha Min¹,*,
View ORCID ProfileLip Ket Chin¹,²,*,
View ORCID ProfileJuhyun Oh¹,
View ORCID ProfileChristian Landeros¹,³,
View ORCID ProfileClaudio Vinegoni¹,
View ORCID ProfileJeeyeon Lee⁴,
View ORCID ProfileSoo Jung Lee⁵,
View ORCID ProfileJee Young Park⁶,
View ORCID ProfileAi-Qun Liu ²,
View ORCID ProfileCesar M. Castro ¹,⁷,
View ORCID ProfileHakho Lee ¹,⁸,†,
View ORCID ProfileHyungsoon Im ¹,⁸,† and
View ORCID ProfileRalph Weissleder ¹,⁸,⁹,†

¹Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
²School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore.
³Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁴Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea.
⁵Department of Oncology/Hematology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea.
⁶Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea.
⁷Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.
⁸Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
⁹Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

↵†Corresponding author. Email: rweissleder{at}mgh.harvard.edu (R.W.); im.hyungsoon{at}mgh.harvard.edu (H.I.); hlee{at}mgh.harvard.edu (H.L.)

↵* These authors contributed equally to the manuscript.

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Science Translational Medicine 05 Aug 2020:
Vol. 12, Issue 555, eaaz9746
DOI: 10.1126/scitranslmed.aaz9746

Jouha Min

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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Lip Ket Chin

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

2School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore.

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Juhyun Oh

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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Christian Landeros

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

3Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Claudio Vinegoni

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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Jeeyeon Lee

4Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea.

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Soo Jung Lee

5Department of Oncology/Hematology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea.

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Jee Young Park

6Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea.

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Ai-Qun Liu

2School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore.

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Cesar M. Castro

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

7Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.

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Hakho Lee

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

8Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

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For correspondence: rweissleder@mgh.harvard.edu im.hyungsoon@mgh.harvard.edu hlee@mgh.harvard.edu

Hyungsoon Im

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

8Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

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For correspondence: rweissleder@mgh.harvard.edu im.hyungsoon@mgh.harvard.edu hlee@mgh.harvard.edu

Ralph Weissleder

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

8Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

9Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

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For correspondence: rweissleder@mgh.harvard.edu im.hyungsoon@mgh.harvard.edu hlee@mgh.harvard.edu

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