Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche

Zhiping Liu; Jiean Xu; Qian Ma; Xiaoyu Zhang; Qiuhua Yang; Lina Wang; Yapeng Cao; Zhimin Xu; Amany Tawfik; Ye Sun; Neal L. Weintraub; David J. Fulton; Mei Hong; Zheng Dong; Lois E. H. Smith; Ruth B. Caldwell; Akrit Sodhi; Yuqing Huo

doi:10.1126/scitranslmed.aay1371

Research ArticleOPHTHALMOLOGY

Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche

View ORCID ProfileZhiping Liu ¹,²,
View ORCID ProfileJiean Xu¹,²,
Qian Ma²,
View ORCID ProfileXiaoyu Zhang²,
Qiuhua Yang²,
Lina Wang²,
Yapeng Cao²,
Zhimin Xu²,
View ORCID ProfileAmany Tawfik ³,⁴,
Ye Sun ⁵,
Neal L. Weintraub ²,
View ORCID ProfileDavid J. Fulton ²,
Mei Hong ¹,⁶,
Zheng Dong⁷,⁸,
View ORCID ProfileLois E. H. Smith ⁵,
View ORCID ProfileRuth B. Caldwell ²,⁴,⁷,⁸,*,
View ORCID ProfileAkrit Sodhi⁹ and
View ORCID ProfileYuqing Huo ²,⁴,⁷,*,†

¹State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
²Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
³Department of Oral Biology and Anatomy, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
⁴James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
⁵Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
⁶Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China.
⁷Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
⁸Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30912, USA.
⁹Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.

↵†Corresponding author. Email: yhuo{at}augusta.edu

↵* These authors contributed equally to this work as co-senior authors.

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Science Translational Medicine 05 Aug 2020:
Vol. 12, Issue 555, eaay1371
DOI: 10.1126/scitranslmed.aay1371

Zhiping Liu

1State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

2Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

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Jiean Xu

1State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

2Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

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Qian Ma

2Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

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Xiaoyu Zhang

2Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

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Qiuhua Yang

2Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

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Lina Wang

2Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

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Yapeng Cao

2Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

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Zhimin Xu

2Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

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Amany Tawfik

3Department of Oral Biology and Anatomy, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.

4James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

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Ye Sun

5Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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Neal L. Weintraub

2Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

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David J. Fulton

2Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

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Mei Hong

1State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

6Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China.

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Zheng Dong

7Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

8Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30912, USA.

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Lois E. H. Smith

5Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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Ruth B. Caldwell

2Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

4James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

7Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

8Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30912, USA.

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Akrit Sodhi

9Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.

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Yuqing Huo

2Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

4James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

7Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

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For correspondence: yhuo@augusta.edu

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Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche

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