Research ArticleMetabolism

Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling

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Science Translational Medicine  05 Aug 2020:
Vol. 12, Issue 555, eaax8096
DOI: 10.1126/scitranslmed.aax8096

Article Information

vol. 12 no. 555

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 25, 2019
  • Resubmitted November 4, 2019
  • Accepted for publication July 16, 2020
  • .

Author Information

  1. Zhenqi Zhou1,
  2. Timothy M. Moore1,
  3. Brian G. Drew1,
  4. Vicent Ribas1,
  5. Jonathan Wanagat2,
  6. Mete Civelek3,
  7. Mayuko Segawa1,
  8. Dane M. Wolf1,
  9. Frode Norheim3,
  10. Marcus M. Seldin3,
  11. Alexander R. Strumwasser1,
  12. Kate A. Whitney1,
  13. Ellen Lester1,
  14. Britany R. Reddish1,
  15. Laurent Vergnes3,
  16. Karen Reue3,
  17. Prashant Rajbhandari4,
  18. Peter Tontonoz4,
  19. Jason Lee5,
  20. Sushil K. Mahata6,7,
  21. Sylvia C. Hewitt8,
  22. Orian Shirihai1,
  23. Craig Gastonbury9,
  24. Kerrin S. Small9,
  25. Markku Laakso10,
  26. Jorgen Jensen11,
  27. Sindre Lee12,
  28. Christian A. Drevon12,
  29. Kenneth S. Korach8,
  30. Aldons J. Lusis3 and
  31. Andrea L. Hevener1,13,*
  1. 1Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
  2. 2Division of Geriatrics, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
  3. 3Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  4. 4Department of Pathology and Laboratory Medicine and the Howard Hughes Research Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  5. 5Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  6. 6VA San Diego Healthcare System, San Diego, CA 92161, USA.
  7. 7Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
  8. 8Receptor Biology Section, NIEHS, NIH, Research Triangle Park, NC 27709, USA.
  9. 9Department of Twin Research and Genetic Epidemiology, King's College London, London SE17EH, UK.
  10. 10Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.
  11. 11Department of Physical Performance, Norwegian School of Sport Science, Oslo 0806, Norway.
  12. 12University Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo 0316, Norway.
  13. 13Iris Cantor-UCLA Women’s Health Research Center, Los Angeles, CA 90095, USA.
  1. *Corresponding author. Email: ahevener{at}mednet.ucla.edu

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