Contents
05 August 2020
Vol 12, Issue 555
Vol 12, Issue 555
Research Articles
- CytoPAN—Portable cellular analyses for rapid point-of-care cancer diagnosis
An automated image cytometry system was developed to enable rapid cancer profiling of scant cellular specimens obtained by fine needle aspiration.
- Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype
Drug tolerance in EGFR-inhibited mCRC involves secretory pseudodifferentiation and rewiring of oncogenic dependencies.
- Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling
ERα gene expression is heritable in humans and prevents obesity in mice by improving mitochondrial function via adipocyte Polg1 expression.
- Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche
Increased glycolysis facilitates reciprocal activation between myeloid cells and endothelial cells in pathological retinal angiogenesis.
- An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates
Replicating RNA vaccine delivered by lipid inorganic nanoparticles induces neutralizing antibody and T cells against SARS-CoV-2 in mice and macaques.
Editors' Choice
- Confetti illuminates the cryptic way calorie restriction protects from cancer
Calorie restriction increases intestinal stem cell competition and decreases the retention of stem cells with mutations in mice.
- Chrono-immunization with BCG: It is about “time”!
Morning vaccination with BCG enhances immunity.
- Not all fibroblasts are equal in cancer
The ratio of two cancer-associated fibroblast subpopulations with distinct functions affects breast cancer clinical outcomes.
About The Cover
ONLINE COVER One Machine to Test Them All. The device depicted here is an automated image cytometry system for point-of-care diagnosis and subtyping of breast cancer. Under current conditions, the accurate diagnosis of cancer can take months in low-resource settings, greatly decreasing the chances of timely and successful treatment. In contrast, the device designed by Min et al. can provide an accurate diagnosis of a biopsy sample in as little as one hour, with minimal operator training and at a much lower cost than currently available methods. [CREDIT: JOUHA MIN, LIP KET CHIN]
