Research ArticleKidney Disease

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease

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Science Translational Medicine  29 Jul 2020:
Vol. 12, Issue 554, eaba3613
DOI: 10.1126/scitranslmed.aba3613

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Antioxidants dominate ADPKD

Autosomal dominant polycystic kidney disease (ADPKD) is a relatively common genetic disorder whose pathogenesis is only partially understood. By studying both human patients and mouse models, Lu et al. identified inactivating mutations of the antioxidant protein NRF2 as playing a key role in the pathogenesis of this disorder. In addition to clarifying the mechanism of disease development, the authors demonstrated that pharmacologic induction of the NRF2 pathway slows the progression of disease in mouse models, suggesting a potential intervention for human patients.

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