Research ArticleCARDIOMYOPATHY

Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy

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Science Translational Medicine  29 Jul 2020:
Vol. 12, Issue 554, eaax9276
DOI: 10.1126/scitranslmed.aax9276

Article Information

vol. 12 no. 554

PubMed: 
Print ISSN: 
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History: 
  • Received for publication May 6, 2019
  • Resubmitted February 13, 2020
  • Accepted for publication July 9, 2020
  • .

Author Information

  1. Nazish Sayed1,2,3,*,,
  2. Chun Liu1,2,3,*,
  3. Mohamed Ameen1,2,
  4. Farhan Himmati1,2,
  5. Joe Z. Zhang1,2,
  6. Saereh Khanamiri1,2,
  7. Jan-Renier Moonen1,4,5,
  8. Alexa Wnorowski1,6,
  9. Linling Cheng1,
  10. June-Wha Rhee1,2,3,
  11. Sadhana Gaddam7,
  12. Kevin C. Wang7,
  13. Karim Sallam1,2,3,
  14. Jack H. Boyd1,8,
  15. Y. Joseph Woo1,8,
  16. Marlene Rabinovitch1,4,5 and
  17. Joseph C. Wu1,2,3,9,
  1. 1Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  2. 2Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  3. 3Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  4. 4Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  5. 5Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, CA 94305, USA.
  6. 6Department of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, USA.
  7. 7Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  8. 8Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  9. 9Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  1. Corresponding author. Email: joewu{at}stanford.edu (J.C.W.); sayedns{at}stanford.edu (N.S.)
  • * These authors contributed equally to this work.

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