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Research ArticlePulmonary Arterial Hypertension
Cellular senescence impairs the reversibility of pulmonary arterial hypertension
- View ORCID ProfileDiederik E. van der Feen1,*,
- Guido P. L. Bossers1,
- View ORCID ProfileQuint A. J. Hagdorn1,
- View ORCID ProfileJan-Renier Moonen2,
- Kondababu Kurakula3,
- View ORCID ProfileRobert Szulcek4,
- View ORCID ProfileJames Chappell2,
- View ORCID ProfileFrancesco Vallania5,6,
- Michele Donato5,6,
- View ORCID ProfileKlaas Kok7,
- Jaskaren S. Kohli8,
- Arjen H. Petersen9,
- Tom van Leusden10,
- View ORCID ProfileMarco Demaria8,
- View ORCID ProfileMarie-José T. H. Goumans3,
- View ORCID ProfileRudolf A. De Boer10,
- View ORCID ProfilePurvesh Khatri5,6,
- Marlene Rabinovitch2,
- View ORCID ProfileRolf M. F. Berger1 and
- View ORCID ProfileBeatrijs Bartelds1,†
- 1Center for Congenital Heart Diseases, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
- 2Department of Pediatrics, Vera Moulton Wall Center for Pulmonary Vascular Disease and the Cardiovascular Institute, Stanford School of Medicine, Stanford, CA 94305, USA.
- 3Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
- 4Department of Pulmonology, VU University Medical Center, 1081 HV Amsterdam, Netherlands.
- 5Institute for Immunity, Transplantation and Infection, Stanford School of Medicine, Stanford, CA 94305, USA.
- 6Stanford Center of Biomedical Informatics Research, Department of Medicine, Stanford, CA 94305, USA.
- 7Department of Genetics, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
- 8European Research Institute for the Biology of Ageing, 9700 AD Groningen, Netherlands.
- 9Department of Medical Biology, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
- 10Department of Experimental Cardiology, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
- ↵*Corresponding author. Email: d.e.van.der.feen01{at}umcg.nl
↵† Present address: Division of Cardiology, Department of Pediatrics, Erasmus University Medical Center, Rotterdam, the Netherlands.
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Science Translational Medicine 29 Jul 2020:
Vol. 12, Issue 554, eaaw4974
DOI: 10.1126/scitranslmed.aaw4974
Vol. 12, Issue 554, eaaw4974
DOI: 10.1126/scitranslmed.aaw4974
Diederik E. van der Feen
1Center for Congenital Heart Diseases, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
Guido P. L. Bossers
1Center for Congenital Heart Diseases, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
Quint A. J. Hagdorn
1Center for Congenital Heart Diseases, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
Jan-Renier Moonen
2Department of Pediatrics, Vera Moulton Wall Center for Pulmonary Vascular Disease and the Cardiovascular Institute, Stanford School of Medicine, Stanford, CA 94305, USA.
Kondababu Kurakula
3Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
Robert Szulcek
4Department of Pulmonology, VU University Medical Center, 1081 HV Amsterdam, Netherlands.
James Chappell
2Department of Pediatrics, Vera Moulton Wall Center for Pulmonary Vascular Disease and the Cardiovascular Institute, Stanford School of Medicine, Stanford, CA 94305, USA.
Francesco Vallania
5Institute for Immunity, Transplantation and Infection, Stanford School of Medicine, Stanford, CA 94305, USA.
6Stanford Center of Biomedical Informatics Research, Department of Medicine, Stanford, CA 94305, USA.
Michele Donato
5Institute for Immunity, Transplantation and Infection, Stanford School of Medicine, Stanford, CA 94305, USA.
6Stanford Center of Biomedical Informatics Research, Department of Medicine, Stanford, CA 94305, USA.
Klaas Kok
7Department of Genetics, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
Jaskaren S. Kohli
8European Research Institute for the Biology of Ageing, 9700 AD Groningen, Netherlands.
Arjen H. Petersen
9Department of Medical Biology, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
Tom van Leusden
10Department of Experimental Cardiology, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
Marco Demaria
8European Research Institute for the Biology of Ageing, 9700 AD Groningen, Netherlands.
Marie-José T. H. Goumans
3Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
Rudolf A. De Boer
10Department of Experimental Cardiology, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
Purvesh Khatri
5Institute for Immunity, Transplantation and Infection, Stanford School of Medicine, Stanford, CA 94305, USA.
6Stanford Center of Biomedical Informatics Research, Department of Medicine, Stanford, CA 94305, USA.
Marlene Rabinovitch
2Department of Pediatrics, Vera Moulton Wall Center for Pulmonary Vascular Disease and the Cardiovascular Institute, Stanford School of Medicine, Stanford, CA 94305, USA.
Rolf M. F. Berger
1Center for Congenital Heart Diseases, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
Beatrijs Bartelds
1Center for Congenital Heart Diseases, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
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