Research ArticlePulmonary Arterial Hypertension

Cellular senescence impairs the reversibility of pulmonary arterial hypertension

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Science Translational Medicine  29 Jul 2020:
Vol. 12, Issue 554, eaaw4974
DOI: 10.1126/scitranslmed.aaw4974

Article Information

vol. 12 no. 554

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 27, 2018
  • Resubmitted October 26, 2019
  • Accepted for publication June 4, 2020
  • .

Author Information

  1. Diederik E. van der Feen1,*,
  2. Guido P. L. Bossers1,
  3. Quint A. J. Hagdorn1,
  4. Jan-Renier Moonen2,
  5. Kondababu Kurakula3,
  6. Robert Szulcek4,
  7. James Chappell2,
  8. Francesco Vallania5,6,
  9. Michele Donato5,6,
  10. Klaas Kok7,
  11. Jaskaren S. Kohli8,
  12. Arjen H. Petersen9,
  13. Tom van Leusden10,
  14. Marco Demaria8,
  15. Marie-José T. H. Goumans3,
  16. Rudolf A. De Boer10,
  17. Purvesh Khatri5,6,
  18. Marlene Rabinovitch2,
  19. Rolf M. F. Berger1 and
  20. Beatrijs Bartelds1,
  1. 1Center for Congenital Heart Diseases, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  2. 2Department of Pediatrics, Vera Moulton Wall Center for Pulmonary Vascular Disease and the Cardiovascular Institute, Stanford School of Medicine, Stanford, CA 94305, USA.
  3. 3Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
  4. 4Department of Pulmonology, VU University Medical Center, 1081 HV Amsterdam, Netherlands.
  5. 5Institute for Immunity, Transplantation and Infection, Stanford School of Medicine, Stanford, CA 94305, USA.
  6. 6Stanford Center of Biomedical Informatics Research, Department of Medicine, Stanford, CA 94305, USA.
  7. 7Department of Genetics, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  8. 8European Research Institute for the Biology of Ageing, 9700 AD Groningen, Netherlands.
  9. 9Department of Medical Biology, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  10. 10Department of Experimental Cardiology, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  1. *Corresponding author. Email: d.e.van.der.feen01{at}umcg.nl
  • Present address: Division of Cardiology, Department of Pediatrics, Erasmus University Medical Center, Rotterdam, the Netherlands.

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