29 July 2020
Vol 12, Issue 554

About The Cover

Cover image expansion

ONLINE COVER Protecting Kidneys from Cystic Disease. This computed tomography scan shows the kidneys of a patient with autosomal dominant polycystic kidney disease, a genetic disorder associated with the continued development of renal cysts and progressively worsening kidney function. In this image, most of one kidney has been replaced by cysts (red). Lu et al. discovered that inactivation of the antioxidant protein NRF2 plays a key role in the pathogenesis of this disease. The authors identified pharmacological interventions that activated the NRF2 pathway and slowed the progression of autosomal dominant polycystic kidney disease in mouse models. [CREDIT: ZEPHYR/SCIENCE SOURCE]