Research ArticleMalaria

Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

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Science Translational Medicine  22 Jul 2020:
Vol. 12, Issue 553, eabb4757
DOI: 10.1126/scitranslmed.abb4757

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Above and beyond antibody abundance

Vaccine development can be hampered by a lack of clear correlates of protection. Suscovich et al. applied systems serology to samples from studies with the RTS,S/AS01 vaccine to understand which antibody functions were associated with protection from controlled malaria challenge, as magnitude of antibody response alone was not predictive. Systems serology revealed that a very small number of parameters involving engagement of innate immune cells could predict protection; this was confirmed with data from two additional studies. Experiments with antibodies in vitro or administered to mice further demonstrated the importance of Fc-mediated functions and innate immunity for protection from malaria parasites. This study emphasizes that finding correlates of protection requires investigation beyond measuring antibody abundance.

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