Research ArticleCOAGULATION

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation

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Science Translational Medicine  22 Jul 2020:
Vol. 12, Issue 553, eaar8430
DOI: 10.1126/scitranslmed.aar8430

Article Information

vol. 12 no. 553

PubMed: 
Print ISSN: 
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History: 
  • Received for publication December 22, 2017
  • Resubmitted March 12, 2020
  • Accepted for publication June 5, 2020
  • .

Author Information

  1. Maria V. Selvadurai1,*,
  2. Mitchell J. Moon1,*,
  3. Simon J. Mountford2,
  4. Xiao Ma2,
  5. Zhaohua Zheng2,
  6. Ian G. Jennings2,
  7. Natasha M. Setiabakti1,3,
  8. Rizani P. Iman1,3,
  9. Rose J. Brazilek1,
  10. Nurul Aisha Z. Abidin1,
  11. Gaëtan Chicanne4,
  12. Sonia Severin4,
  13. Alyce J. Nicholls5,
  14. Connie H.Y. Wong5,
  15. Jean-Yves Rinckel6,
  16. Anita Eckly6,
  17. Christian Gachet6,
  18. Warwick S. Nesbitt1,7,
  19. Philip E. Thompson2 and
  20. Justin R. Hamilton1,
  1. 1Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia.
  2. 2Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  3. 3Faculty of Medicine, Universitas Indonesia, Salemba, Jakarta 10430, Indonesia.
  4. 4Institut des Maladies Métaboliques et Cardiovasculaires, Inserm U1048, Université Toulouse III, 31432 Toulouse CEDEX 4, France.
  5. 5Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, Clayton, VIC 3800, Australia.
  6. 6Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S 1255, FMTS, F-67000 Strasbourg, France.
  7. 7Microplatforms Research Group, School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.
  1. Corresponding author. Email: justin.hamilton{at}monash.edu
  • * These authors contributed equally to this work.

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