Contents
Vol 12, Issue 553
Research Articles
- siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice
Targeted siRNA nanoparticles can specifically inhibit pro-atherogenic macrophage pathways to combat atherosclerotic vascular disease.
- Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation
First-generation PI3KC2α inhibitors prevent thrombosis without causing bleeding.
- Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents
Optogenetic hearing restoration in rodents by LED-based multichannel optical cochlear implants provides improved spectral selectivity.
- Apoptosis of hematopoietic progenitor-derived adipose tissue–resident macrophages contributes to insulin resistance after myocardial infarction
Myocardial infarction promotes insulin resistance via apoptosis of macrophages in visceral adipose tissue.
- Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination
A combination of two Fc antibody features that leverage innate immune function predicts protection from malaria challenge after RTS,S/AS01 vaccination.
Editors' Choice
- Could gut flora cycles be key to treating diabetes?
Gut microbiota abundance rhythms are ablated in patients with type 2 diabetes.
- Loss of TET2 boosts cell fitness
The loss of TET2 favors a pathogenic switch to a stem cell–like state in cancer.
- Brain structural changes in sync with the cycle
Neuroimaging and hormone assays over a full menstrual cycle reveal the effects of ovarian hormones on gray matter volumes in a patient.
About The Cover

ONLINE COVER Preventing Plaque Progression. This image shows a section of the aortic root immunostained for macrophages (Mac2, green), CaMKIIγ (red), and DAPI (blue) from a mouse with atherosclerosis. Tao et al. demonstrated that targeted small interfering RNA (siRNA) nanoparticles can selectively silence CaMKIIγ in atherogenic lesional macrophages, which helped stabilize plaques and reduced necrotic area in a mouse model of atherosclerosis. Results demonstrate the therapeutic potential of using siRNA nanoparticles to target atherosclerosis-promoting genes in plaque macrophages. [CREDIT: ARIF YURDAGUL JR.]