Contents

Research Articles

• siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

  By Wei Tao, Arif Yurdagul, Jr., Na Kong, Wenliang Li, Xiaobo Wang, Amanda C. Doran, Chan Feng, Junqing Wang, Mohammad Ariful Islam, Omid C. Farokhzad, Ira Tabas, Jinjun Shi

  Science Translational Medicine22 Jul 2020 Full AccessRestricted Access

  Targeted siRNA nanoparticles can specifically inhibit pro-atherogenic macrophage pathways to combat atherosclerotic vascular disease.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation

  By Maria V. Selvadurai, Mitchell J. Moon, Simon J. Mountford, Xiao Ma, Zhaohua Zheng, Ian G. Jennings, Natasha M. Setiabakti, Rizani P. Iman, Rose J. Brazilek, Nurul Aisha Z. Abidin, Gaëtan Chicanne, Sonia Severin, Alyce J. Nicholls, Connie H.Y. Wong, Jean-Yves Rinckel, Anita Eckly, Christian Gachet, Warwick S. Nesbitt, Philip E. Thompson, Justin R. Hamilton

  Science Translational Medicine22 Jul 2020 Full AccessRestricted Access

  First-generation PI3KC2α inhibitors prevent thrombosis without causing bleeding.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents

  By Daniel Keppeler, Michael Schwaerzle, Tamas Harczos, Lukasz Jablonski, Alexander Dieter, Bettina Wolf, Suleman Ayub, Christian Vogl, Christian Wrobel, Gerhard Hoch, Khaled Abdellatif, Marcus Jeschke, Vladan Rankovic, Oliver Paul, Patrick Ruther, Tobias Moser

  Science Translational Medicine22 Jul 2020 Full AccessRestricted Access

  Optogenetic hearing restoration in rodents by LED-based multichannel optical cochlear implants provides improved spectral selectivity.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• Apoptosis of hematopoietic progenitor-derived adipose tissue–resident macrophages contributes to insulin resistance after myocardial infarction

  By Sathish Babu Vasamsetti, Emilie Coppin, Xinyi Zhang, Jonathan Florentin, Sasha Koul, Matthias Götberg, Andrew S. Clugston, Floyd Thoma, John Sembrat, Grant C. Bullock, Dennis Kostka, Claudette M. St. Croix, Ansuman Chattopadhyay, Mauricio Rojas, Suresh R. Mulukutla, Partha Dutta

  Science Translational Medicine22 Jul 2020 Full AccessRestricted Access

  Myocardial infarction promotes insulin resistance via apoptosis of macrophages in visceral adipose tissue.

  • Editor's Summary
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  • Supplementary Materials

• Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

  By Todd J. Suscovich, Jonathan K. Fallon, Jishnu Das, Allison R. Demas, Jonathan Crain, Caitlyn H. Linde, Ashlin Michell, Harini Natarajan, Claudia Arevalo, Thomas Broge, Thomas Linnekin, Viraj Kulkarni, Richard Lu, Matthew D. Slein, Corinne Luedemann, Meghan Marquette, Sandra March, Joshua Weiner, Scott Gregory, Margherita Coccia, Yevel Flores-Garcia, Fidel Zavala, Margaret E. Ackerman, Elke Bergmann-Leitner, Jenny Hendriks, Jerald Sadoff, Sheetij Dutta, Sangeeta N. Bhatia, Douglas A. Lauffenburger, Erik Jongert, Ulrike Wille-Reece, Galit Alter

  Science Translational Medicine22 Jul 2020 Full AccessRestricted Access

  A combination of two Fc antibody features that leverage innate immune function predicts protection from malaria challenge after RTS,S/AS01 vaccination.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials