22 July 2020
Vol 12, Issue 553

About The Cover

Cover image expansion

ONLINE COVER Preventing Plaque Progression. This image shows a section of the aortic root immunostained for macrophages (Mac2, green), CaMKIIγ (red), and DAPI (blue) from a mouse with atherosclerosis. Tao et al. demonstrated that targeted small interfering RNA (siRNA) nanoparticles can selectively silence CaMKIIγ in atherogenic lesional macrophages, which helped stabilize plaques and reduced necrotic area in a mouse model of atherosclerosis. Results demonstrate the therapeutic potential of using siRNA nanoparticles to target atherosclerosis-promoting genes in plaque macrophages. [CREDIT: ARIF YURDAGUL JR.]