Research ArticleCancer

Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance

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Science Translational Medicine  15 Jul 2020:
Vol. 12, Issue 552, eaaw7843
DOI: 10.1126/scitranslmed.aaw7843

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Helping macrophages battle glioblastoma

Although most cancer therapies target the tumor cells themselves, the tumor microenvironment also plays a key role in patients’ outcomes. Akkari et al. examined the interaction between radiation therapy, a mainstay of treatment for the brain tumor glioblastoma, and innate immune cells in the tumor microenvironment. The authors focused on two immune cell types, brain-resident microglia and monocyte-derived macrophages, and identified radiation-induced changes in protein abundance and gene expression in both cell types. On the basis of these findings, the authors selected a pharmacological treatment that enhanced the efficacy of radiotherapy in mouse models of glioblastoma.

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