08 July 2020
Vol 12, Issue 551

About The Cover

Cover image expansion

ONLINE COVER Painful Deficiency. This image shows epidermal innervation in a patient with CDKL5 deficiency disorder (CDD), an X-linked disorder characterized by developmental epileptic encephalopathy. To better understand the disease phenotype, La Montanara et al. studied patients with CDD and noted alterations in pain perception. The authors showed that CDKL5 is expressed in sensory neurons and controls nociception. In rodents, Cdkl5 deletion reduced pain sensitivity by modulating calcium-dependent TRPV1 signaling. Pain perception assessment and restoration should be considered for patients with CDD. [CREDIT: J. CLARK, B. HARRISON/UNIVERSITY OF NEW ENGLAND; P. LA MONTANARA/IMPERIAL COLLEGE LONDON]