01 July 2020
Vol 12, Issue 550

About The Cover

Cover image expansion

ONLINE COVER A One-Two Punch Against Mesothelioma. This image depicts immunohistochemical staining of mesothelioma, a rare but aggressive lung tumor with very limited therapeutic options. The marker stained in brown is mesothelin, a protein that is highly expressed in mesothelioma, but not in most normal adult tissues. Jiang et al. showed that mouse models and patients with mesothelioma become more sensitive to immune checkpoint blockade after treatment with an immunotoxin targeting mesothelin, resulting in greatly improved therapeutic outcomes. [CREDIT: MARKKU MIETTINEN/NATIONAL CANCER INSTITUTE]