Contents

Research Articles

• Enhanced efficacy of mesothelin-targeted immunotoxin LMB-100 and anti–PD-1 antibody in patients with mesothelioma and mouse tumor models

  By Qun Jiang, Azam Ghafoor, Idrees Mian, Daniel Rathkey, Anish Thomas, Christine Alewine, Manjistha Sengupta, Mark A. Ahlman, Jingli Zhang, Betsy Morrow, Seth M. Steinberg, Ira Pastan, Raffit Hassan

  Science Translational Medicine01 Jul 2020 Full AccessRestricted Access

  Mesothelin-targeted immunotoxin LMB-100 with anti–PD-1 antibody enhanced antitumor activity in patients with mesothelioma and mouse tumor models.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• Circulating transcripts in maternal blood reflect a molecular signature of early-onset preeclampsia

  By Sarah Munchel, Suzanne Rohrback, Carlo Randise-Hinchliff, Sarah Kinnings, Shweta Deshmukh, Nagesh Alla, Catherine Tan, Amirali Kia, Grainger Greene, Linda Leety, Matthew Rhoa, Scott Yeats, Matthew Saul, Julia Chou, Kimberley Bianco, Kevin O’Shea, Emmanuel Bujold, Errol Norwitz, Ronald Wapner, George Saade, Fiona Kaper

  Science Translational Medicine01 Jul 2020 Full AccessRestricted Access

  Circulating transcripts reflect biologically relevant changes in early-onset severe preeclampsia and can accurately classify patient status.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• Intestinal goblet cells protect against GVHD after allogeneic stem cell transplantation via Lypd8

  By Takahide Ara, Daigo Hashimoto, Eiko Hayase, Clara Noizat, Ryo Kikuchi, Yuta Hasegawa, Kana Matsuda, Shoko Ono, Yoshihiro Matsuno, Ko Ebata, Reiki Ogasawara, Shuichiro Takahashi, Hiroyuki Ohigashi, Emi Yokoyama, Keitaro Matsuo, Junichi Sugita, Masahiro Onozawa, Ryu Okumura, Kiyoshi Takeda, Takanori Teshima

  Science Translational Medicine01 Jul 2020 Full AccessRestricted Access

  Goblet cells play a protective role against GVHD after allogeneic stem cell transplantation in a Lypd8-dependent manner.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• An ultrafast insulin formulation enabled by high-throughput screening of engineered polymeric excipients

  By Joseph L. Mann, Caitlin L. Maikawa, Anton A. A. Smith, Abigail K. Grosskopf, Sam W. Baker, Gillie A. Roth, Catherine M. Meis, Emily C. Gale, Celine S. Liong, Santiago Correa, Doreen Chan, Lyndsay M. Stapleton, Anthony C. Yu, Ben Muir, Shaun Howard, Almar Postma, Eric A. Appel

  Science Translational Medicine01 Jul 2020 Full AccessRestricted Access

  Monomeric insulin stabilized with polymeric excipient exhibits increased stability and faster pharmacokinetics than current rapid-acting insulins.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials