A rapidly deployable individualized system for augmenting ventilator capacity

Shriya S. Srinivasan; Khalil B. Ramadi; Francesco Vicario; Declan Gwynne; Alison Hayward; David Lagier; Robert Langer; Joseph J. Frassica; Rebecca M. Baron; Giovanni Traverso

doi:10.1126/scitranslmed.abb9401

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A rapidly deployable individualized system for augmenting ventilator capacity

View ORCID ProfileShriya S. Srinivasan¹,²,³,
View ORCID ProfileKhalil B. Ramadi¹,²,³,
View ORCID ProfileFrancesco Vicario⁴,
Declan Gwynne¹,²,³,
View ORCID ProfileAlison Hayward²,³,⁵,
View ORCID ProfileDavid Lagier⁶,
View ORCID ProfileRobert Langer¹,³,⁷,⁸,
View ORCID ProfileJoseph J. Frassica⁴,⁸,
Rebecca M. Baron ⁹ and
View ORCID ProfileGiovanni Traverso¹,²,³,*

¹Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
²Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
³David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁴Philips Research North America, Cambridge, MA 02141, USA.
⁵Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁶Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02139, USA.
⁷Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁸Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁹Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

↵*Corresponding author. Email: cgt20{at}mit.edu, ctraverso{at}bwh.harvard.edu

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Science Translational Medicine 24 Jun 2020:
Vol. 12, Issue 549, eabb9401
DOI: 10.1126/scitranslmed.abb9401

Shriya S. Srinivasan

1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

3David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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ORCID record for Shriya S. Srinivasan

Khalil B. Ramadi

1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

3David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Francesco Vicario

4Philips Research North America, Cambridge, MA 02141, USA.

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Declan Gwynne

1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

3David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Alison Hayward

2Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

3David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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David Lagier

6Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02139, USA.

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Robert Langer

1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

8Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Joseph J. Frassica

4Philips Research North America, Cambridge, MA 02141, USA.

8Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Rebecca M. Baron

9Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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Giovanni Traverso

1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

3David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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For correspondence: cgt20@mit.edu ctraverso@bwh.harvard.edu

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