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Research ResourceCancer
Patient-derived tumor-like cell clusters for drug testing in cancer therapy
- View ORCID ProfileShenyi Yin1,*,
- View ORCID ProfileRuibin Xi2,*,
- Aiwen Wu3,*,
- View ORCID ProfileShu Wang4,*,
- View ORCID ProfileYingjie Li3,
- View ORCID ProfileChaobin Wang4,
- Lei Tang3,
- Yuchao Xia2,
- Di Yang1,
- Juan Li1,
- View ORCID ProfileBuqing Ye1,
- View ORCID ProfileYing Yu1,
- Junyi Wang1,
- Hanshuo Zhang1,5,
- Fei Ren4,
- Yuanyuan Zhang4,
- Danhua Shen4,
- View ORCID ProfileLin Wang3,
- Xiangji Ying3,
- View ORCID ProfileZhongwu Li3,
- View ORCID ProfileZhaode Bu3,
- Xin Ji3,
- View ORCID ProfileXiangyu Gao3,
- View ORCID ProfileYongning Jia3,
- View ORCID ProfileZiyu Jia3,
- Nan Li3,
- View ORCID ProfileZiyu Li3,
- View ORCID ProfileJia-Fu Ji3,† and
- View ORCID ProfileJianzhong Jeff Xi1,†
- 1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
- 2School of Mathematical Sciences, Center for Statistical Science and Department of Biostatistics, Peking University, Beijing 100871, China.
- 3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
- 4Peking University People’s Hospital, Beijing 100044, China.
- 5GeneX Health Co. Ltd., Beijing 100195, China.
- ↵†Corresponding author. Email: jijiafu{at}hsc.pku.edu.cn (J.-F.J.); jzxi{at}pku.edu.cn (J.J.X.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 24 Jun 2020:
Vol. 12, Issue 549, eaaz1723
DOI: 10.1126/scitranslmed.aaz1723
Vol. 12, Issue 549, eaaz1723
DOI: 10.1126/scitranslmed.aaz1723
Shenyi Yin
1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
Ruibin Xi
2School of Mathematical Sciences, Center for Statistical Science and Department of Biostatistics, Peking University, Beijing 100871, China.
Aiwen Wu
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Shu Wang
4Peking University People’s Hospital, Beijing 100044, China.
Yingjie Li
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Chaobin Wang
4Peking University People’s Hospital, Beijing 100044, China.
Lei Tang
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Yuchao Xia
2School of Mathematical Sciences, Center for Statistical Science and Department of Biostatistics, Peking University, Beijing 100871, China.
Di Yang
1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
Juan Li
1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
Buqing Ye
1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
Ying Yu
1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
Junyi Wang
1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
Hanshuo Zhang
1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
5GeneX Health Co. Ltd., Beijing 100195, China.
Fei Ren
4Peking University People’s Hospital, Beijing 100044, China.
Yuanyuan Zhang
4Peking University People’s Hospital, Beijing 100044, China.
Danhua Shen
4Peking University People’s Hospital, Beijing 100044, China.
Lin Wang
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Xiangji Ying
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Zhongwu Li
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Zhaode Bu
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Xin Ji
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Xiangyu Gao
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Yongning Jia
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Ziyu Jia
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Nan Li
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Ziyu Li
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Jia-Fu Ji
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
Jianzhong Jeff Xi
1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
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