Patient-derived tumor-like cell clusters for drug testing in cancer therapy

Shenyi Yin; Ruibin Xi; Aiwen Wu; Shu Wang; Yingjie Li; Chaobin Wang; Lei Tang; Yuchao Xia; Di Yang; Juan Li; Buqing Ye; Ying Yu; Junyi Wang; Hanshuo Zhang; Fei Ren; Yuanyuan Zhang; Danhua Shen; Lin Wang; Xiangji Ying; Zhongwu Li; Zhaode Bu; Xin Ji; Xiangyu Gao; Yongning Jia; Ziyu Jia; Nan Li; Ziyu Li; Jia-Fu Ji; Jianzhong Jeff Xi

doi:10.1126/scitranslmed.aaz1723

Research ResourceCancer

Patient-derived tumor-like cell clusters for drug testing in cancer therapy

View ORCID ProfileShenyi Yin¹,*,
View ORCID ProfileRuibin Xi ²,*,
Aiwen Wu ³,*,
View ORCID ProfileShu Wang⁴,*,
View ORCID ProfileYingjie Li³,
View ORCID ProfileChaobin Wang⁴,
Lei Tang³,
Yuchao Xia²,
Di Yang¹,
Juan Li¹,
View ORCID ProfileBuqing Ye¹,
View ORCID ProfileYing Yu¹,
Junyi Wang¹,
Hanshuo Zhang¹,⁵,
Fei Ren⁴,
Yuanyuan Zhang⁴,
Danhua Shen⁴,
View ORCID ProfileLin Wang³,
Xiangji Ying³,
View ORCID ProfileZhongwu Li³,
View ORCID ProfileZhaode Bu³,
Xin Ji³,
View ORCID ProfileXiangyu Gao³,
View ORCID ProfileYongning Jia³,
View ORCID ProfileZiyu Jia³,
Nan Li³,
View ORCID ProfileZiyu Li³,
View ORCID ProfileJia-Fu Ji ³,† and
View ORCID ProfileJianzhong Jeff Xi ¹,†

¹State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
²School of Mathematical Sciences, Center for Statistical Science and Department of Biostatistics, Peking University, Beijing 100871, China.
³Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.
⁴Peking University People’s Hospital, Beijing 100044, China.
⁵GeneX Health Co. Ltd., Beijing 100195, China.

↵†Corresponding author. Email: jijiafu{at}hsc.pku.edu.cn (J.-F.J.); jzxi{at}pku.edu.cn (J.J.X.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 24 Jun 2020:
Vol. 12, Issue 549, eaaz1723
DOI: 10.1126/scitranslmed.aaz1723

Shenyi Yin

1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.

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Ruibin Xi

2School of Mathematical Sciences, Center for Statistical Science and Department of Biostatistics, Peking University, Beijing 100871, China.

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Aiwen Wu

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Shu Wang

4Peking University People’s Hospital, Beijing 100044, China.

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Yingjie Li

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Chaobin Wang

4Peking University People’s Hospital, Beijing 100044, China.

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Lei Tang

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Yuchao Xia

2School of Mathematical Sciences, Center for Statistical Science and Department of Biostatistics, Peking University, Beijing 100871, China.

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Di Yang

1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.

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Juan Li

1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.

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Buqing Ye

1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.

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Ying Yu

1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.

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Junyi Wang

1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.

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Hanshuo Zhang

1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.

5GeneX Health Co. Ltd., Beijing 100195, China.

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Fei Ren

4Peking University People’s Hospital, Beijing 100044, China.

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Yuanyuan Zhang

4Peking University People’s Hospital, Beijing 100044, China.

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Danhua Shen

4Peking University People’s Hospital, Beijing 100044, China.

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Lin Wang

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Xiangji Ying

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Zhongwu Li

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Zhaode Bu

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Xin Ji

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Xiangyu Gao

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Yongning Jia

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Ziyu Jia

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Nan Li

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Ziyu Li

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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Jia-Fu Ji

3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing 100083, China.

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For correspondence: jijiafu@hsc.pku.edu.cn jzxi@pku.edu.cn

Jianzhong Jeff Xi

1State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.

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For correspondence: jijiafu@hsc.pku.edu.cn jzxi@pku.edu.cn

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