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Patient-derived tumor-like cell clusters for drug testing in cancer therapy

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Science Translational Medicine  24 Jun 2020:
Vol. 12, Issue 549, eaaz1723
DOI: 10.1126/scitranslmed.aaz1723

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Little clusters with big promise

Despite recent advances in medicine, identifying the optimal treatment regimen for each patient with cancer remains difficult and often imprecise. There are now multiple methods for analyzing a tumor’s drug sensitivity, including tumor organoids and patient-derived xenografts, but each has its own drawbacks such as a lack of tumor stroma or the time required to obtain results. The approach designed by Yin et al., patient-derived tumor-like cell clusters, aims to overcome some of these shortcomings by using ex vivo culture of tumor cells together with their stroma. Initial testing of this method has shown promising results when applied to patients with several different tumor types.

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