cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy

Wenwen Li; Lu Lu; Juanjuan Lu; Xinran Wang; Chao Yang; Jingsi Jin; Lingling Wu; Xiaochuan Hong; Fanlin Li; Dongqing Cao; Yuanqin Yang; Meng Wu; Bing Su; Jinke Cheng; Xuanming Yang; Wen Di; Liufu Deng

doi:10.1126/scitranslmed.aay9013

Research ArticleCancer

cGAS-STING–mediated DNA sensing maintains CD8⁺ T cell stemness and promotes antitumor T cell therapy

View ORCID ProfileWenwen Li ¹,*,
View ORCID ProfileLu Lu¹,*,
Juanjuan Lu²,
Xinran Wang³,
Chao Yang²,
Jingsi Jin²,
Lingling Wu²,
Xiaochuan Hong²,
View ORCID ProfileFanlin Li⁴,
Dongqing Cao²,
Yuanqin Yang²,
Meng Wu ²,
Bing Su²,
View ORCID ProfileJinke Cheng⁵,
View ORCID ProfileXuanming Yang⁴,†,
View ORCID ProfileWen Di ³,† and
View ORCID ProfileLiufu Deng ¹,†

¹Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital and Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
²Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
³Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
⁴Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.
⁵Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

↵†Corresponding author. Email: dengliufu{at}shsmu.edu.cn (L.D.); diwen{at}renji.com (W.D.); xuanmingyang{at}sjtu.edu.cn (X.Y.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 24 Jun 2020:
Vol. 12, Issue 549, eaay9013
DOI: 10.1126/scitranslmed.aay9013

Wenwen Li

1Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital and Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

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Lu Lu

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Juanjuan Lu

2Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

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Xinran Wang

3Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

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Chao Yang

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Jingsi Jin

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Lingling Wu

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Xiaochuan Hong

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Fanlin Li

4Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.

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Dongqing Cao

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Yuanqin Yang

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Meng Wu

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Bing Su

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Jinke Cheng

5Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

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Xuanming Yang

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For correspondence: dengliufu@shsmu.edu.cn diwen@renji.com xuanmingyang@sjtu.edu.cn

Wen Di

3Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

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For correspondence: dengliufu@shsmu.edu.cn diwen@renji.com xuanmingyang@sjtu.edu.cn

Liufu Deng

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For correspondence: dengliufu@shsmu.edu.cn diwen@renji.com xuanmingyang@sjtu.edu.cn

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cGAS-STING–mediated DNA sensing maintains CD8⁺ T cell stemness and promotes antitumor T cell therapy

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