Research ArticleCancer

cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy

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Science Translational Medicine  24 Jun 2020:
Vol. 12, Issue 549, eaay9013
DOI: 10.1126/scitranslmed.aay9013

Article Information

vol. 12 no. 549

PubMed: 
Print ISSN: 
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History: 
  • Received for publication July 29, 2019
  • Resubmitted February 3, 2020
  • Accepted for publication May 28, 2020
  • .

Author Information

  1. Wenwen Li1,*,
  2. Lu Lu1,*,
  3. Juanjuan Lu2,
  4. Xinran Wang3,
  5. Chao Yang2,
  6. Jingsi Jin2,
  7. Lingling Wu2,
  8. Xiaochuan Hong2,
  9. Fanlin Li4,
  10. Dongqing Cao2,
  11. Yuanqin Yang2,
  12. Meng Wu2,
  13. Bing Su2,
  14. Jinke Cheng5,
  15. Xuanming Yang4,,
  16. Wen Di3, and
  17. Liufu Deng1,
  1. 1Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital and Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  2. 2Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  3. 3Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
  4. 4Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.
  5. 5Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  1. Corresponding author. Email: dengliufu{at}shsmu.edu.cn (L.D.); diwen{at}renji.com (W.D.); xuanmingyang{at}sjtu.edu.cn (X.Y.)
  • * These authors contributed equally to this work.

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