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Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma

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Science Translational Medicine  10 Jun 2020:
Vol. 12, Issue 547, eaay2163
DOI: 10.1126/scitranslmed.aay2163

Article Information

vol. 12 no. 547

PubMed: 
Print ISSN: 
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History: 
  • Received for publication May 30, 2019
  • Accepted for publication May 4, 2020
  • .

Author Information

  1. Madi Y. Cissé1,2,
  2. Samuel Pyrdziak1,2,*,
  3. Nelly Firmin1,2,3,*,
  4. Laurie Gayte1,2,
  5. Maud Heuillet4,5,
  6. Floriant Bellvert4,5,
  7. Maryse Fuentes1,2,
  8. Hélène Delpech1,2,
  9. Romain Riscal1,2,
  10. Giuseppe Arena1,2,
  11. Frédéric Chibon6,
  12. Sophie Le Gellec6,7,
  13. Aurélie Maran-Gonzalez3,
  14. Marie-Christine Chateau3,
  15. Charles Theillet1,2,
  16. Sébastien Carrere1,2,3,
  17. Jean-Charles Portais4,5,8,
  18. Laurent Le Cam1,2,*, and
  19. Laetitia K. Linares1,2,*,
  1. 1IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, Montpellier F-34298, France.
  2. 2Equipe Labélisée par la Ligue contre le Cancer, Paris F-75013, France.
  3. 3Institut régional du Cancer Montpellier, Montpellier F-34298, France.
  4. 4TBI, Université de Toulouse, CNRS, INRA, INSA, Toulouse F-31400, France.
  5. 5MetaToul-MetaboHUB, National Infrastructure of Metabolomics and Fluxomics, Toulouse F-31077, France.
  6. 6INSERM UMR 1037, Centre de Recherche en Cancérologie de Toulouse, Université Paul Sabatier Toulouse-III, Toulouse F-31100, France.
  7. 7Department of Pathology, Institut Claudius Regaud, IUCT-Oncopole, Toulouse F-31100, France.
  8. 8Université Paul Sabatier, Université de Toulouse, Toulouse F-31062, France.
  1. Corresponding author. Email: laetitia.linares{at}inserm.fr (L.K.L.); laurent.lecam{at}inserm.fr (L.L.C.)
  • * These authors contributed equally to this work.

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