Contents
Vol 12, Issue 547
Research Articles
- Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis
An inkjet-printed nanochip integrating multiparametric extracellular vesicle analyses monitors tumor burden via liquid biopsy.
- Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles
The autism-associated protein SHANK3 is essential for the maturation of neuromuscular junctions and striated muscles.
- Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality
Analysis of antibodies elicited by related Zika virus DNA vaccines revealed protection correlates with a capacity to neutralize mature virions.
- Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma
Chromatin-bound MDM2 regulates serine metabolism and nucleotide synthesis to sustain tumor growth in liposarcoma.
- A direct-acting antiviral drug abrogates viremia in Zika virus–infected rhesus macaques
Galidesivir, a broad-spectrum direct-acting adenosine analog antiviral drug, abrogates viremia in rhesus macaques infected with Zika virus.
Review
- Locoregional delivery of stem cell–based therapies
Image-guided, minimally invasive procedures target delivery of stem cell–based therapies to regenerate, replace, or repair damaged tissues and organs.
Editors' Choice
- Cancer cells harness insulin for performance enhancement
Hyperinsulinemia and insulin receptor signaling allow cancer cells to evade cell competition.
- The story of COVID-19: A comparative analysis
COVID-19 induces a distinct host transcriptome.
- Cancer-immune topology influences lung cancer evolution
The extent of lymphocyte infiltration controls cancer subclone divergence, and a single immune cold region can increase the risk of relapse.
About The Cover

ONLINE COVER Capturing Clues about Cancer. This scanning electron microscopy image shows a nanopatterned microfluidic chip. Chips can be used to detect and analyze tumor-associated extracellular vesicles (EVs) from liquid biopsies (blood, saliva, or other biofluids). Zhang et al. used three-dimensional silica colloidal inkjet printing to create chips that detect the expression and activity of matrix metalloproteinase 14 bound to EVs. Using the chips, they monitored the invasiveness of breast cancer cell lines and mouse tumor models and classified subtypes of breast cancer from clinical plasma samples. Nanopatterned chips provide a noninvasive platform for cancer diagnosis and surveillance. [CREDIT: ZHANG ET AL./SCIENCE TRANSLATIONAL MEDICINE]