10 June 2020
Vol 12, Issue 547

About The Cover

Cover image expansion

ONLINE COVER Capturing Clues about Cancer. This scanning electron microscopy image shows a nanopatterned microfluidic chip. Chips can be used to detect and analyze tumor-associated extracellular vesicles (EVs) from liquid biopsies (blood, saliva, or other biofluids). Zhang et al. used three-dimensional silica colloidal inkjet printing to create chips that detect the expression and activity of matrix metalloproteinase 14 bound to EVs. Using the chips, they monitored the invasiveness of breast cancer cell lines and mouse tumor models and classified subtypes of breast cancer from clinical plasma samples. Nanopatterned chips provide a noninvasive platform for cancer diagnosis and surveillance. [CREDIT: ZHANG ET AL./SCIENCE TRANSLATIONAL MEDICINE]