Contents

Research Articles

• Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis

  By Peng Zhang, Xiaoqing Wu, Gulhumay Gardashova, Yang Yang, Yaohua Zhang, Liang Xu, Yong Zeng

  Science Translational Medicine10 Jun 2020 Full AccessRestricted Access

  An inkjet-printed nanochip integrating multiparametric extracellular vesicle analyses monitors tumor burden via liquid biopsy.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles

  By Anne-Kathrin Lutz, Stefanie Pfaender, Berra Incearap, Valentin Ioannidis, Ilaria Ottonelli, Karl J. Föhr, Judith Cammerer, Marvin Zoller, Julia Higelin, Federica Giona, Maximilian Stetter, Nicole Stoecker, Najwa Ouali Alami, Michael Schön, Michael Orth, Stefan Liebau, Gotthold Barbi, Andreas M. Grabrucker, Richard Delorme, Michael Fauler, Benjamin Mayer, Sarah Jesse, Francesco Roselli, Albert C. Ludolph, Thomas Bourgeron, Chiara Verpelli, Maria Demestre, Tobias M. Boeckers

  Science Translational Medicine10 Jun 2020 Full AccessRestricted Access

  The autism-associated protein SHANK3 is essential for the maturation of neuromuscular junctions and striated muscles.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality

  By Sonia Maciejewski, Tracy J. Ruckwardt, Kaitlyn M. Morabito, Bryant M. Foreman, Katherine E. Burgomaster, David N. Gordon, Rebecca S. Pelc, Christina R. DeMaso, Sung-Youl Ko, Brian E. Fisher, Eun Sung Yang, Deepika Nair, Kathryn E. Foulds, John Paul Todd, Wing-Pui Kong, Vicky Roy, Maya Aleshnick, Scott D. Speer, Nigel Bourne, Alan D. Barrett, Martha C. Nason, Mario Roederer, Martin R. Gaudinski, Grace L. Chen, Kimberly A. Dowd, Julie E. Ledgerwood, Galit Alter, John R. Mascola, Barney S. Graham, Theodore C. Pierson

  Science Translational Medicine10 Jun 2020 Full AccessRestricted Access

  Analysis of antibodies elicited by related Zika virus DNA vaccines revealed protection correlates with a capacity to neutralize mature virions.

  • Editor's Summary
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  • Supplementary Materials

• Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma

  By Madi Y. Cissé, Samuel Pyrdziak, Nelly Firmin, Laurie Gayte, Maud Heuillet, Floriant Bellvert, Maryse Fuentes, Hélène Delpech, Romain Riscal, Giuseppe Arena, Frédéric Chibon, Sophie Le Gellec, Aurélie Maran-Gonzalez, Marie-Christine Chateau, Charles Theillet, Sébastien Carrere, Jean-Charles Portais, Laurent Le Cam, Laetitia K. Linares

  Science Translational Medicine10 Jun 2020 Full AccessRestricted Access

  Chromatin-bound MDM2 regulates serine metabolism and nucleotide synthesis to sustain tumor growth in liposarcoma.

  • Editor's Summary
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  • Supplementary Materials

• A direct-acting antiviral drug abrogates viremia in Zika virus–infected rhesus macaques

  By So-Yon Lim, Christa E. Osuna, Katharine Best, Ray Taylor, Elsa Chen, Gyeol Yoon, Jessica L. Kublin, Dane Schalk, Nancy Schultz-Darken, Saverio Capuano, David Safronetz, Ma Luo, Steve MacLennan, Amanda Mathis, Yarlagadda S. Babu, William P. Sheridan, Alan S. Perelson, James B. Whitney

  Science Translational Medicine10 Jun 2020 Full AccessRestricted Access

  Galidesivir, a broad-spectrum direct-acting adenosine analog antiviral drug, abrogates viremia in rhesus macaques infected with Zika virus.

  • Editor's Summary
  • Abstract
  • Full Text
  • PDF
  • Supplementary Materials