Research ArticleAtherosclerosis

Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis

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Science Translational Medicine  03 Jun 2020:
Vol. 12, Issue 546, eaaz2294
DOI: 10.1126/scitranslmed.aaz2294

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Autophagy and atherosclerosis

Autophagy is one mechanism by which cells adapt to stress. Here, Santovito et al. investigated the role of microRNA (miR) 126-5p in endothelial cell autophagy in atherosclerosis. The authors observed that high shear stress promoted trafficking of miR-126-5p to the nucleus of endothelial cells where it had antiapoptotic effects via direct interaction with caspase-3. This pathway was present in the aortas of mouse models of atherosclerosis and samples of diseased vessels from humans. Results uncover a noncanonical mechanism by which miR-126-5p prevents endothelial dysfunction.

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