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Research ArticleHIV
An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells
- View ORCID ProfileQian Wang1,*,
- View ORCID ProfileShan Su1,*,
- View ORCID ProfileJing Xue2,*,
- Fei Yu3,
- Jing Pu1,
- View ORCID ProfileWenwen Bi1,
- View ORCID ProfileShuai Xia1,
- View ORCID ProfileYu Meng1,
- View ORCID ProfileCong Wang1,
- Wenqian Yang1,
- View ORCID ProfileWei Xu1,
- View ORCID ProfileYun Zhu4,
- View ORCID ProfileQinwen Zheng1,
- View ORCID ProfileChuan Qin2,†,
- View ORCID ProfileShibo Jiang1,5,† and
- View ORCID ProfileLu Lu1,†
- 1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
- 2Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Re-emerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China.
- 3College of Life and Science, Hebei Agricultural University, Baoding 071001, China.
- 4National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
- 5Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
- ↵†Corresponding author. Email: lul{at}fudan.edu.cn (L.L.); shibojiang{at}fudan.edu.cn (S.J.); qinchuan{at}pumc.edu.cn (C.Q.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 03 Jun 2020:
Vol. 12, Issue 546, eaaz2254
DOI: 10.1126/scitranslmed.aaz2254
Vol. 12, Issue 546, eaaz2254
DOI: 10.1126/scitranslmed.aaz2254
Qian Wang
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
Shan Su
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
Jing Xue
2Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Re-emerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China.
Fei Yu
3College of Life and Science, Hebei Agricultural University, Baoding 071001, China.
Jing Pu
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
Wenwen Bi
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
Shuai Xia
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
Yu Meng
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
Cong Wang
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
Wenqian Yang
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
Wei Xu
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
Yun Zhu
4National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Qinwen Zheng
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
Chuan Qin
2Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Re-emerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China.
Shibo Jiang
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
5Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
Lu Lu
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
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