Research ArticleHIV

An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells

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Science Translational Medicine  03 Jun 2020:
Vol. 12, Issue 546, eaaz2254
DOI: 10.1126/scitranslmed.aaz2254

Article Information

vol. 12 no. 546

Print ISSN: 
Online ISSN: 
  • Received for publication August 22, 2019
  • Accepted for publication April 28, 2020
  • .

Author Information

  1. Qian Wang1,*,
  2. Shan Su1,*,
  3. Jing Xue2,*,
  4. Fei Yu3,
  5. Jing Pu1,
  6. Wenwen Bi1,
  7. Shuai Xia1,
  8. Yu Meng1,
  9. Cong Wang1,
  10. Wenqian Yang1,
  11. Wei Xu1,
  12. Yun Zhu4,
  13. Qinwen Zheng1,
  14. Chuan Qin2,,
  15. Shibo Jiang1,5, and
  16. Lu Lu1,
  1. 1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, 130 Dong An Rd., Xuhui District, Shanghai 200032, China.
  2. 2Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Re-emerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China.
  3. 3College of Life and Science, Hebei Agricultural University, Baoding 071001, China.
  4. 4National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  5. 5Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
  1. Corresponding author. Email: lul{at} (L.L.); shibojiang{at} (S.J.); qinchuan{at} (C.Q.)
  • * These authors contributed equally to this work.


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