Research ArticleCancer

Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia

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Science Translational Medicine  03 Jun 2020:
Vol. 12, Issue 546, eaaz0463
DOI: 10.1126/scitranslmed.aaz0463

Article Information

vol. 12 no. 546

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 7, 2019
  • Resubmitted January 20, 2020
  • Accepted for publication April 21, 2020
  • .

Author Information

  1. Jayakumar Vadakekolathu1,
  2. Mark D. Minden2,
  3. Tressa Hood3,
  4. Sarah E. Church3,
  5. Stephen Reeder1,
  6. Heidi Altmann4,
  7. Amy H. Sullivan3,
  8. Elena J. Viboch3,
  9. Tasleema Patel5,
  10. Narmin Ibrahimova2,
  11. Sarah E. Warren3,
  12. Andrea Arruda2,
  13. Yan Liang3,
  14. Thomas H. Smith3,
  15. Gemma A. Foulds1,
  16. Michael D. Bailey3,
  17. James Gowen-MacDonald3,
  18. John Muth6,
  19. Marc Schmitz7,8,9,
  20. Alessandra Cesano3,
  21. A. Graham Pockley1,10,
  22. Peter J. M. Valk11,
  23. Bob Löwenberg11,
  24. Martin Bornhäuser4,8,9,
  25. Sarah K. Tasian5,
  26. Michael P. Rettig12,
  27. Jan K. Davidson-Moncada6,
  28. John F. DiPersio12 and
  29. Sergio Rutella1,10,*
  1. 1John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham NG11 8NS, UK.
  2. 2Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada.
  3. 3NanoString Technologies Inc., Seattle, WA 98109, USA.
  4. 4Department of Medicine, Universitätsklinikum Carl Gustav Carus, 01307 Dresden, Germany.
  5. 5Department of Pediatrics, Division of Oncology and Centre for Childhood Cancer Research, Children’s Hospital of Philadelphia and University of Pennsylvania School of Medicine, PA 19104, USA.
  6. 6MacroGenics Inc., Rockville, MD 20850, USA.
  7. 7Institute of Immunology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
  8. 8National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany.
  9. 9German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  10. 10Centre for Health, Ageing and Understanding Disease (CHAUD), Nottingham Trent University, Nottingham NG11 8NS, UK.
  11. 11Department of Hematology, Erasmus University Medical Centre, 3000CA Rotterdam, Netherlands.
  12. 12Division of Oncology, Department of Internal Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
  1. *Corresponding author. Email: sergio.rutella{at}ntu.ac.uk

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