Research ArticleGENE EDITING

Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function

See allHide authors and affiliations

Science Translational Medicine  03 Jun 2020:
Vol. 12, Issue 546, eaay6422
DOI: 10.1126/scitranslmed.aay6422

Article Information

vol. 12 no. 546

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 5, 2019
  • Resubmitted December 9, 2019
  • Accepted for publication April 13, 2020
  • .

Author Information

  1. Yuchi Honaker1,
  2. Nicholas Hubbard1,*,,
  3. Yufei Xiang1,*,
  4. Logan Fisher1,,
  5. David Hagin1,§,
  6. Karen Sommer1,
  7. Yumei Song1,
  8. Soo Jung Yang2,
  9. Christina Lopez1,
  10. Tori Tappen2,
  11. Elizabeth M. Dam2,||,
  12. Iram Khan1,
  13. Malika Hale1,
  14. Jane H. Buckner2,3,4,
  15. Andrew M. Scharenberg1,4,5,,#,
  16. Troy R. Torgerson1,4,5 and
  17. David J. Rawlings1,4,5,#
  1. 1Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children’s Research Institute, Seattle, WA 98101, USA.
  2. 2Benaroya Research Institute, Seattle, WA 98101, USA.
  3. 3Department of Medicine, University of Washington, Seattle, WA 98101, USA.
  4. 4Department of Immunology, University of Washington, Seattle, WA 98101, USA.
  5. 5Department of Pediatrics, University of Washington, Seattle, WA 98101, USA.
  1. #Corresponding author. Email: drawling{at}uw.edu (D.J.R.); andrewms{at}uw.edu (A.M.S.)
  • * These authors contributed equally to this work.

  • Present address: Department of Immunology, University of Washington, Seattle, WA 98101, USA.

  • Present address: Immunobiology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20817, USA.

  • § Present address: Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

  • || Present address: Nohla Therapeutics, Seattle, WA 98102, USA.

  • Present address: Umoja Biopharma, Seattle, WA 98103, USA.

Altmetric

Article usage

Article usage: June 2020 to October 2020

AbstractFullPdf
Jun 202054571409694
Jul 202063713098
Aug 2020989174115
Sep 202044313176
Oct 20203506345

Stay Connected to Science Translational Medicine