03 June 2020
Vol 12, Issue 546

About The Cover

Cover image expansion

ONLINE COVER Benefits of Base Editing. This image shows the basal portion of the mouse cochlea, part of the inner ear involved in hearing. Recessive point mutations in the transmembrane channel-like 1 (TMC1) gene cause abnormal hair cell morphology and hearing loss. Yeh et al. developed a mouse model of recessive hearing loss due to a point mutation in Tmc1. In vivo base gene editing in newborn mice partially corrected the mutation, improving sensory hair cell morphology and transiently rescuing auditory function. The results suggest that base editing might be effective for treating recessive forms of hearing loss. [CREDIT: YEH ET AL./SCIENCE TRANSLATIONAL MEDICINE]